Myosin VIIa Antibody

• Catalog number
  bs-7761R
• Price
  Please ask
• Size
  0.1ml

• Long name
  Myosin VIIa Primary Polyclonal Antibody
• Also known as
  Myosin VIIa PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  Myosin VIIa
• Specificity
  This is a highly specific antibody against Myosin VIIa.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  875-910/2215
• Subcellular location
  Cytoplasm
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Myosin VIIa
• Gene ID number
  4647
• Swiss Prot
  Q13402
• Tested Applications
  IHC-P, IF(IHC-P)
• Recommended dilutions
  IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity (By similarity). Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  DFNB2; MYU7A; NSRD2; USH1B; DFNA11; MYOVIIA; Unconventional myosin-VIIa; MYO7A
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Myosin   VIIa  
• Gene symbol
  MYO7A, MYRIP
• Short name
  Anti-Myosin VIIa
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  Myosin VIIa Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:7606
• Gene
  MYO7A
• Long gene name
  myosin VIIA
• Synonyms gene
  • USH1B
  • DFNB2
  • DFNA11
• Synonyms gene name
  • myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))
• Synonyms
  • NSRD2
• GenBank acession
  • U39226
• Locus
  11q13.5
• Discovery year
  1992-06-08
• Entrez gene record
  4647
• Pubmed identfication
  • 8884266
• RefSeq identity
  • NM_000260
• Classification
  • Myosin heavy chains, class VII
  • FERM domain containing
  • A-kinase anchoring proteins
• VEGA ID
  OTTHUMG00000152822
• Locus Specific Databases
  • Hereditary Hearing Loss Homepage
  • Mutations of the Myosin VIIa Gene
  • CCHMC-BMI & UC Hearing Loss Mutation Database
  • LRG_1420

Gene info

• Identity
  HGNC:19156
• Gene
  MYRIP
• Long gene name
  myosin VIIA and Rab interacting protein
• Synonyms
  • DKFZp586F1018
  • exophilin-8
  • SLAC2-C
  • SLAC2C
• Synonyms name
  • synaptotagmin-like protein homologue lacking C2 domains-c
  • rab effector MYRIP
  • Slp homologue lacking C2 domains
• GenBank acession
  • AF396687
• Locus
  3p22.1
• Discovery year
  2002-09-13
• Entrez gene record
  25924
• Pubmed identfication
  • 11964381
  • 12221080
  • 17827149
• RefSeq identity
  • NM_015460
• Classification
  • A-kinase anchoring proteins
• VEGA ID
  OTTHUMG00000131392

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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