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Target antigen
Mucin Gastric
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Clonality
Monoclonal antibody
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Clone
45M1
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Raised in
mice
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Type of the antibody
IgG1 monoclonal antibody
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Product form
freeze-dried
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Reacts with species
Human, mouse, rabbit, rat
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Analyses
WB,IHC-P,ICC
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Immunogen
Mucin from human ovarian cyst fluid.
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Product configuration
Mouse ascites fluid, 1.2% Na acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
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Purification
Ascites
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Solubilization
The powdered antibody should be dissolved in 1ml of PBS buffer to achieve final concentration of 100ug/ml.
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Storage condtions
Keep the Mucin Gastric Antibody ( 45M1)at minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Mucin Gastric Antibody ( 45M1) did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
Mucin 5AC (Muc5AC) is a protein that in humans is encoded by the MUC5AC gene. Using real-time RT-PCR, Moehle et al. (2006) found that MUC5AC was highly expressed in adult trachea and stomach. Expression was lower in adult lung and weak in fetal lung, and no expression was detected in other tissues. This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease. Moreover, Muc5ac is identified as a direct and critical mediator of resistance during intestinal nematode infection.
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Related articles
1. Hasnain, S. Z., Evans, C. M., Roy, M., Gallagher, A. L., Kindrachuk, K. N., Barron, L., Dickey, B. F., Wilson, M. S., Wynn, T. A., Grencis, R. K., Thornton, D. J. Muc5ac: a critical component mediating the rejection of enteric nematodes. J. Exp. Med. 208: 893-900, 2011. 2. Moehle, C., Ackermann, N., Langmann, T., Aslanidis, C., Kel, A., Kel-Margoulis, O., Schmitz-Madry, A., Zahn, A., Stremmel, W., Schmitz, G. Aberrant intestinal expression and allelic variants of mucin genes associated with inflammatory bowel disease. J. Molec. Med. 84: 1055-1066, 2006.
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Gene Name
MUC5AC
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Protein Name
Mucin-5AC
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Gene Full Name
mucin 5AC, oligomeric mucus/gel-forming
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Synonyms
Apomucin|Gastric mucin|LeB|Lewis B blood group antigen|Major Airway Glycoprotein|MUC 5|MUC5|MUC5AC|Mucin 5 subtype AC tracheobronchial|Mucin 5 Subtypes A And C|Mucin 5 subtypes A and C tracheobronchial/gastric|Mucin 5AC|Mucin 5AC oligomeric mucus/gel forming|Mucin 5AC, oligomeric mucus/gel forming pseudogene|TBM|Tracheobronchial Mucin
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Uniprot ID
Human(P98088)
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Entrez GeneID
Human(4586), Mouse(17833), Rat(682837)
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
