MEIS2 Antibody, Cy7 Conjugated

  • Catalog number
  • Product name
    MEIS2 Antibody, Cy7 Conjugated
  • Size
  • Price
  • Supplier
    Bioss Primary Conjugated Antibodies
  • Long name
    MEIS2 Polyclonal Antibody, Cy7 Conjugated
  • Category
    Conjugated Primary Antibodies
  • Conjugation
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
  • Specificity
    This is a highly specific antibody against MEIS2.
  • Modification
  • Modification site
  • Clonality
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Source
    KLH conjugated synthetic peptide derived from human MEIS2
  • Tested applications
  • Recommended dilutions
  • Crossreactivity
    Human, Mouse, Rat
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background
    Hox, Pbx and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains. Hox proteins are involved in regulating tissue patterning during development, and are also expressed in lineage- and stage-specific patterns during adult hematopoietic differentiation and in leukemias. The Hox proteins, which include paralog groups 1-10, have a low intrinsic binding affinity for DNA and are instead associated into cooperative DNA binding complexes with Pbx or the Pbx- related Meis proteins, which result in an enhanced Hox-DNA binding affinity and an increased selectivity for the binding site. Both Meis1 and Meis2 (also known as Meis-related gene 1 or Mrg1) are members of the TALE (“three amino acid loop extension”) family of homeodomain-containing proteins. In addition to binding with Hox proteins, Meis1 also forms heterodimers with the ubiquitously expressed Pbx proteins, including Pbx1, Pbx2 and Pbx3, and these complexes contain distinct DNA-binding specificities. Like Hox and Pbx proteins, Meis1 is implicated in oncogenesis, as it is overexpressed as a result of adjacent retroviral insertion in BHX-2 myeloid leukemias. Two Meis-related proteins, Meis2 and Meis3 (also designated Mrg1 and Mrg2, respectively), possess largely similar sequence identity with Meis1 and are expressed in normal tissues and myeloid leukemias. In the pancreas, Meis2 preferentially associates with Pbx1, and together they associate with the pancreas-specific homeodomain factor, Pdx1, to repress Pdx1-induced transcriptional activation.
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission
  • Synonyms
    Homeobox protein Meis2; HsT18361; Meis mouse homolog 2; Meis homeobox 2; Meis homolog 2; Meis1 myeloid ecotropic viral integration site 1 homolog 2 mouse; Meis1 myeloid ecotropic viral integration site 1 homolog 2 antibodyMeis1 related gene 1; Meis1 related protein 1; Meis1-related protein 1; MEIS2; MEIS2_HUMAN; MGC2820; MRG1; TALE homeobox protein Meis2
  • group_crc32
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Conjugated
    These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.
  • Additional conjugation
  • French translation
  • Gene target
  • Short name
    MEIS2 Antibody, Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Label
  • Alternative name
    MEIS2 (Antibody to), cyanine 7 coupled
  • Alternative technique
1. Gene info
  • Identity
  • Gene
  • Long gene name
    Meis homeobox 2
  • Synonyms gene name
    • Meis (mouse) homolog 2
    • Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • TALE class homeoboxes and pseudogenes
  • Havana BLAST/BLAT
MeSH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
Additional information
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MEIS2 Antibody, Cy7 Conjugated -
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