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KDM5A Antibody , FITC Conjugated

  • Catalog number
    bs-16947R-FITC
  • Product name
    KDM5A Antibody , FITC Conjugated
  • Size
    0.1ml
  • Price
    333EUR
  • Supplier
    Bioss Primary Conjugated Antibodies
  • Ask
  • Clonality
    Polyclonal
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Antigen background
    Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity).
  • Modification site
    None
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Long name
    KDM5A Polyclonal Antibody , FITC Conjugated
  • Subcellular location
    Nucleus
  • Synonyms
    RBP2; RBBP2; RBBP-2; Lysine-specific demethylase 5A; Histone demethylase JARID1A; Jumonji/ARID domain-containing protein 1A; Retinoblastoma-binding protein 2; KDM5A; JARID1A
  • Gene ID number
    5927
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Conjugation
    FITC
  • Modification
    Unmodified
  • Category
    Conjugated Primary Antibodies
  • Source
    KLH conjugated synthetic peptide derived from human KDM5A
  • Swiss Prot
    P29375
  • Specificity
    This is a highly specific antibody against KDM5A.
  • Tested applications
    IF(IHC-P)
  • Clone
    Polyclonal antibody
  • Crossreactivity
    Human, Mouse, Rat
  • Concentration
    1ug per 1ul
  • Target Antigen
    KDM5A
  • Immunogen_range
    130-160/1690
  • Excitation Emission
    494nm/518nm
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
  • Additional conjugation
    Anti-FITC Antibody
  • Gene target
  • Short name
    KDM5A Antibody FITC Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
  • Label
    FITC
  • Alternative name
    KDM5A (Antibody to) , fluorecein coupled
  • Alternative technique
    antibodies
  • Ask
1. Gene info
  • Identity
  • Gene
  • Long gene name
    lysine demethylase 5A
  • Synonyms gene
  • Synonyms gene name
    • retinoblastoma-binding protein 2
    • Jumonji, AT rich interactive domain 1A (RBBP2-like)
    • jumonji, AT rich interactive domain 1A
    • lysine (K)-specific demethylase 5A
  • Locus
  • Discovery year
    1992-09-17
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • PHD finger proteins
    • Lysine demethylases
    • AT-rich interaction domain containing
    • EMSY complex
  • Havana BLAST/BLAT
MESH Data
  • Name
  • Concept
    Scope note: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
  • Tree numbers
    • E01.370.225.500.607.512.240
    • E01.370.225.750.551.512.240
    • E05.200.500.607.512.240
    • E05.200.750.551.512.240
    • E05.478.583.375
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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