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JAK2 Antibody, Cy5.5 Conjugated

  • Catalog number
    bs-0908R-Cy5.5
  • Product name
    JAK2 Antibody, Cy5.5 Conjugated
  • Size
    0.1ml
  • Price
    350EUR
  • Supplier
    Bioss Primary Conjugated Antibodies
  • Ask
  • Clonality
    Polyclonal
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Antigen background
    Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
  • Modification site
    None
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Long name
    JAK2 Polyclonal Antibody, Cy5.5 Conjugated
  • Subcellular location
    Cytoplasm, Nucleus, Cell membrane
  • Synonyms
    JTK1; THCYT3; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2; JAK2
  • Gene ID number
    3717
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Conjugation
    Cy5.5
  • Modification
    Unmodified
  • Category
    Conjugated Primary Antibodies
  • Source
    KLH conjugated synthetic peptide derived from human JAK2
  • Swiss Prot
    O60674
  • Specificity
    This is a highly specific antibody against JAK2.
  • Tested applications
    IF(IHC-P)
  • Clone
    Polyclonal antibody
  • Crossreactivity
    Human, Mouse, Rat
  • Concentration
    1ug per 1ul
  • Target Antigen
    JAK2
  • Immunogen_range
    623-666/1132
  • Excitation Emission
    675nm/694nm
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
  • Additional conjugation
    Cy5.5, Cy5.5
  • Conjugated
    These antibodies are excite for emission at 678nm and detected at a 694 nm wavelengths.
  • Gene target
  • Short name
    JAK2 Antibody, Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Label
    Cy5.5
  • Alternative name
    Janus kinase 2 (Antibody to), cyanine 5.5 coupled
  • Alternative technique
    antibodies
  • Alternative to gene target
    Janus kinase 2, JTK10 and THCYT3, JAK2 and IDBG-47039 and ENSG00000096968 and 3717, this GO :0000186 and activation of MAPKK activity and biological process this GO :0004672 and protein kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0004715 and non-membrane spanning protein tyrosine kinase activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005131 and growth hormone receptor binding and molecular function this GO :0005143 and interleukin-12 receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005901 and caveola and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006928 and cellular component movement and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007165 and signal transduction and biological process this GO :0007167 and enzyme linked receptor protein signaling pathway and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0007204 and positive regulation of cytosolic calcium ion concentration and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0007260 and tyrosine phosphorylation of STAT protein and biological process this GO :0007262 and STAT protein import into nucleus and biological process this GO :0007498 and mesoderm development and biological process this GO :0007596 and blood coagulation and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008631 and intrinsic apoptotic signaling pathway in response to oxidative stress and biological process this GO :0009755 and hormone-mediated signaling pathway and biological process this GO :0010811 and positive regulation of cell-substrate adhesion and biological process this GO :0014068 and positive regulation of phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016363 and nuclear matrix and cellular component this GO :0016772 and transferase activity, transferring phosphorus-containing groups and molecular function this GO :0018108 and peptidyl-tyrosine phosphorylation and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0019901 and protein kinase binding and molecular function this GO :0020037 and heme binding and molecular function this GO :0022408 and negative regulation of cell-cell adhesion and biological process this GO :0030041 and actin filament polymerization and biological process this GO :0030099 and myeloid cell differentiation and biological process this GO :0030154 and cell differentiation and biological process this GO :0030218 and erythrocyte differentiation and biological process this GO :0030335 and positive regulation of cell migration and biological process this GO :0031103 and axon regeneration and biological process this GO :0031702 and type 1 angiotensin receptor binding and molecular function this GO :0031904 and endosome lumen and cellular component this GO :0031959 and mineralocorticoid receptor signaling pathway and biological process this GO :0032024 and positive regulation of insulin secretion and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032516 and positive regulation of phosphoprotein phosphatase activity and biological process this GO :0032731 and positive regulation of interleukin-1 beta production and biological process this GO :0032760 and positive regulation of tumor necrosis factor production and biological process this GO :0033130 and acetylcholine receptor binding and molecular function this GO :0033160 and positive regulation of protein import into nucleus, translocation and biological process this GO :0033194 and response to hydroperoxide and biological process this GO :0033209 and tumor necrosis factor-mediated signaling pathway and biological process this GO :0034050 and host programmed cell death induced by symbiont and biological process this GO :0034612 and response to tumor necrosis factor and biological process this GO :0035401 and histone kinase activity (H3-Y41 specific) and molecular function this GO :0035409 and histone H3-Y41 phosphorylation and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0035722 and interleukin-12-mediated signaling pathway and biological process this GO :0042169 and SH2 domain binding and molecular function this GO :0042393 and histone binding and molecular function this GO :0042503 and tyrosine phosphorylation of Stat3 protein and biological process this GO :0042506 and tyrosine phosphorylation of Stat5 protein and biological process this GO :0042508 and tyrosine phosphorylation of Stat1 protein and biological process this GO :0042517 and positive regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0042523 and positive regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0042977 and activation of JAK2 kinase activity and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043388 and positive regulation of DNA binding and biological process this GO :0043392 and negative regulation of DNA binding and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043548 and phosphatidylinositol 3-kinase binding and molecular function this GO :0043560 and insulin receptor substrate binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045121 and membrane raft and cellular component this GO :0045429 and positive regulation of nitric oxide biosynthetic process and biological process this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0045822 and negative regulation of heart contraction and biological process this GO :0046677 and response to antibiotic and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0048008 and platelet-derived growth factor receptor signaling pathway and biological process this GO :0050727 and regulation of inflammatory response and biological process this GO :0050729 and positive regulation of inflammatory response and biological process this GO :0050731 and positive regulation of peptidyl-tyrosine phosphorylation and biological process this GO :0050867 and positive regulation of cell activation and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051428 and peptide hormone receptor binding and molecular function this GO :0051770 and positive regulation of nitric-oxide synthase biosynthetic process and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060334 and regulation of interferon-gamma-mediated signaling pathway and biological process this GO :0060396 and growth hormone receptor signaling pathway and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0060399 and positive regulation of growth hormone receptor signaling pathway and biological process this GO :0061180 and mammary gland epithelium development and biological process this GO :0070671 and response to interleukin-12 and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097296 and activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, transferase activity, this GO :0004672: protein kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0004715: non-membrane spanning protein tyrosine kinase activity and also this GO :0005102: receptor binding and also this GO :0005131: growth hormone receptor binding and also this GO :0005143: interleukin-12 receptor binding and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0008022: protein C-terminus binding and also this GO :0016772: transferase activity, transferring phosphorus-containing groups and also this GO :0019901: protein kinase binding and also this GO :0020037: heme binding and also this GO :0031702: type 1 angiotensin receptor binding and also this GO :0033130: acetylcholine receptor binding and also this GO :0035401: histone kinase activity (H3-Y41 specific) and also this GO :0042169: SH2 domain binding and also this GO :0042393: histone binding and also this GO :0043548: phosphatidylinositol 3-kinase binding and also this GO :0043560: insulin receptor substrate binding and also this GO :0051428: peptide hormone receptor binding, this GO :0004672: protein kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0004715: non-membrane spanning protein tyrosine kinase activity, this GO :0005102: receptor binding, this GO :0005131: growth hormone receptor binding, this GO :0005143: interleukin-12 receptor binding, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0008022: protein C-terminus binding, this GO :0016772: transferase activity, transferring phosphorus-containing groups, this GO :0019901: protein kinase binding, this GO :0020037: heme binding, this GO :0031702: type 1 angiotensin receptor binding, this GO :0033130: acetylcholine receptor binding, this GO :0035401: histone kinase activity (H3-Y41 specific), this GO :0042169: SH2 domain binding, this GO :0042393: histone binding, this GO :0043548: phosphatidylinositol 3-kinase binding, this GO :0043560: insulin receptor substrate binding, this GO :0051428: peptide hormone receptor binding, nuclei, Jak2 and IDBG-156977 and ENSMUSG00000024789 and 16452, BT.25287 and IDBG-631361 and ENSBTAG00000012047 and 525246
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1. Gene info
  • Identity
  • Gene
  • Long gene name
    Janus kinase 2
  • Synonyms
  • Locus
  • Discovery year
    1992-04-16
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • SH2 domain containing
    • FERM domain containing
  • Havana BLAST/BLAT
  • Locus Specific Databases
MESH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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