Integrin beta 4 Antibody ITGB4

• Catalog number
  R30790
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Integrin beta 4 ITGB4
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the Integrin beta 4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Integrin beta 4 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P16144
• Purity
  Antigen affinity
• Description
  ITGB4 (Integrin beta 4), also known as CD104 (Cluster of Differentiation 104), is a human gene. The gene encodes the integrin beta 4 subunits, a receptor for the laminins. This subunit tends to associate with alpha 6 subunits and is likely to play a pivotal role in the biology of invasive carcinoma. The ITGB4 gene is mapped on 17q25.1. Using expression profiling, Yang et al. found that ITGB4 was upregulated 6-fold by ZKSCAN3 in transfected human colon cancer cells compared with parental cells. They confirmed that ZKSCAN3 bound the promoter of ITGB4 in vitro and in vivo. ITGB4 knockdown by short hairpin RNA countered ZKSCAN3-augmented anchorage-independent colony formation in the colon cancer cell lines. The integrin beta-4 subunit is characterized by an unusually long cytoplasmic domain that harbors 4 fibronectin type III (FNIII) repeats, residing in 2 pairs separated by a connecting segment. Vidal et al. found compound heterozygosity for mutations in the gene in an infant with junctional epidermolysis bullosa associated with pyloric atresia.
• Immunogen
  An amino acid sequence from the C-terminus of human ITGB4 (TLSTHMDQQFFQT) was used as the immunogen for this Integrin beta 4 antibody.
• Storage
  After reconstitution, the Integrin beta 4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Integrin   beta   ITGB4  
• Gene symbol
  ITGB4
• Short name
  Anti-Integrin beta 4 ITGB4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Integrin beta 4 ITGB4
• Alternative technique
  antibodies
• Alternative to gene target
  integrin, beta 4, CD104, ITGB4 and IDBG-68784 and ENSG00000132470 and 3691, protein binding, Cell surfaces, Itgb4 and IDBG-214382 and ENSMUSG00000020758 and 192897, ITGB4 and IDBG-643160 and ENSBTAG00000018169 and

Gene info

• Identity
  HGNC:6158
• Gene
  ITGB4
• Long gene name
  integrin subunit beta 4
• Synonyms gene name
  • integrin, beta 4
• Synonyms
  • CD104
• Locus
  17q25.1
• Discovery year
  1991-08-06
• Entrez gene record
  3691
• Pubmed identfication
  • 2070796
• Classification
  • Integrin beta subunits
  • Fibronectin type III domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000179814

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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