Hsc70 Antibody

  • Catalog number
    PA1214
  • Product name
    Hsc70 Antibody
  • Size
    0,1 mg
  • Price
    377.79
  • Supplier
    boster
  • Target antigen
    Hsc70
  • Clonality
    Polyclonal antibody
  • Clone
    Polyclonal antibody
  • Raised in
    rabbit
  • Type of the antibody
    IgG polyclonal antibody
  • Product form
    freeze-dried
  • Reacts with species:
    human, mouse, rat
  • Analyses
    WB,IHC-P,IHC-F,ICC
  • Immunogen
    A synthetic peptide corresponding to a sequence at the N-terminus of human Hsc70(13-31aa TTYSCVGVFQHGKVEIIAN), identical to the related rat and mouse sequence.
  • Product configuration
    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
  • Purification
    Immunogen affinity purified.
  • Solubilization
    The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
  • Storage condtions
    Keep the Hsc70 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
  • Tips
    The Hsc70 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
  • Background
    The 70 kilodalton heat shock proteins(Hsp70s) are a family of ubiquitously expressed heat shock proteins. The Hsp70s are an important part of the cell's machinery for protein folding, and help to protect cells from stress. All of the Hsp70 proteins have three major functional domains: An N-terminal ATPase domain binds ATP(Adenosine triphosphate) and hydrolyzes it to ADP(Adenosine diphosphate); A substrate binding domain contains a groove with an affinity for neutral, hydrophobic amino acid residues; A C-terminal domain rich in alpha helical structure acts as a 'lid' for the substrate binding domain. By binding tightly to partially-synthesized peptide sequences(incomplete proteins), Hsp70 prevents them from aggregating and being rendered nonfunctional. And it also can act to protect cells from thermal or oxidative stress. Finally, Hsp70 seems to be able to participate in disposal of damaged or defective proteins. Interaction with CHIP(Carboxyl-terminus of Hsp70 Interacting Protein)–an E3 ubiquitin ligase–allows Hsp70 to pass proteins to the cell's ubiquitination and proteolysis pathways.
  • Related articles
    1. Tavaria M, Gabriele T, Kola I, Anderson RL (April 1996). "A hitchhiker's guide to the human Hsp70 family". Cell Stress Chaperones 1 (1): 23–8. 2. Morano KA (October 2007). "New tricks for an old dog: the evolving world of Hsp70". Ann. N. Y. Acad. Sci. 1113: 1–14. 3. Luders, J.; Demand, J.; Hohfeld, J. (2000), Journal of Biological Chemistry 275 (7): 4613–461, more retrieved on 2009-04-07
  • Gene Name
    HSPA8
  • Protein Name
    Heat shock cognate 71 kDa protein
  • Gene Full Name
    heat shock 70kDa protein 8
  • Synonyms
    2410008N15Rik antibody|Constitutive heat shock protein 70 antibody|Heat shock 70 kDa protein 8 antibody|Heat shock 70kD protein 10 antibody|Heat shock 70kD protein 8 antibody|Heat shock 70kDa protein 8 antibody|Heat shock cognate 71 kDa protein antibody|Heat shock cognate 71 kDa protein. antibody|Heat shock cognate protein 54 antibody|Heat shock cognate protein 71 kDa antibody|Heat shock cognate protein 71-kDa antibody|Heat shock protein 8 antibody|Heat shock protein A8 antibody|Heat-shock70-KD protein 10, formerly antibody|HSC54 antibody|HSC71 antibody|Hsc73 antibody|HSP71 antibody|HSP73 antibody|HSP7C_HUMAN antibody|HSPA10 antibody|HSPA8 antibody|LAP1 antibody|Lipopolysaccharide associated protein 1 antibody|LPS associated protein 1 antibody|LPS associated protein antibody|MGC102007 antibody|MGC106514 antibody|MGC114311 antibody|MGC118485 antibody|MGC131511 antibody|MGC29929 antibody|N-myristoyltransferase inhibitor protein 71 antibody|NIP71 antibody
  • Uniprot ID
    P11142
  • group_crc32
    3828023734
  • Properties
    If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
  • Short name
    Hsc70 Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative name
    Hsc70 (Antibody to)
  • Alternative technique
    antibodies
1. Gene info
  • Identity
  • Gene
  • Long gene name
    heat shock protein family A (Hsp70) member 8
  • Synonyms gene
  • Synonyms gene name
    • heat shock 70kD protein 8
    • heat shock 70kDa protein 8
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1995-05-08
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Heat shock 70kDa proteins
    • NineTeen complex
  • Havana BLAST/BLAT
MeSH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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