HRAS Antibody
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Catalog numberF50750-0.4ML
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PricePlease ask
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Size0.4 ml
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CategoryAntibody
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ConcentrationIn 1X PBS, pH 7.4, with 0.09% sodium azide
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FormPurified
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ConjugationUnconjugated
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ClonePolyclonal antibody
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Recognised antigenHRAS
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Host animalRabbit (Oryctolagus cuniculus)
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ClonalityPolyclonal (rabbit origin)
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Species reactivityHuman (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applicationsWB, IHC, IF, ELISA
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Recommended dilutionsWestern blot: 1:500-1000,IHC (Paraffin): 1:10-1:50,Immunofluorescence: 1:10-1:50
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NotesTitration of the HRAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Intented useThis HRAS antibodyis to be used only for research purposes and not for diagnostics..
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UniprotP01112
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PurityPurified
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DescriptionHRAS belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. These proteins function in signal transduction pathways. They can bind GTP and GDP, and they have intrinsic GTPase activity. HRAS undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in the HRAS gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma.
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ImmunogenA portion of amino acids 104-128 from the human protein was used as the immunogen for this HRAS antibody.
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StorageAliquot the HRAS antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
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PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolHRAS
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Short nameAnti-HRAS
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit Ig
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Alternative nameAntibodies to HRAS
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Alternative techniqueantibodies
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Alternative to gene targetv-Ha-ras Harvey rat sarcoma viral oncogene homolog, C-BAS/HAS and C-H-RAS and C-HA-RAS1 and CTLO and H-RASIDX and HAMSV and HRAS1 and p21ras and RASH1, HRAS and IDBG-16878 and ENSG00000174775 and 3265, ferrous iron transmembrane transporter activity, nuclei, Hras1 and IDBG-212024 and ENSMUSG00000025499 and 15461, HRAS and IDBG-645593 and ENSBTAG00000046644 and 100298939
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Gene info
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Identity
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Gene
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Long gene nameHRas proto-oncogene, GTPase
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Synonyms gene
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Synonyms gene name
- v-Ha-ras Harvey rat sarcoma viral oncogene homolog
- Harvey rat sarcoma viral oncogene homolog
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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RefSeq identity
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Classification
- RAS type GTPase family
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data