Anti-HPV16 E6 protein (2E3) Monoclonal, ALEXA Fluor 594
-
Catalog number
GENTObsm-0990M-A594
-
Price
Please ask
-
Size
100 microliters
-
-
Type
Conjugated Primary Antibody
-
Conjugated with
ALEXA FLUOR 594
-
Host organism
Mouse (Mus musculus)
-
Target Protein Peptide
HPV16 E6 protein
-
Specificity
Highly specific antibody against HPV16 E6 protein
-
Modification
Not modified
-
Clonality
Monoclonal Antibodies
-
Clone
2E3
-
Concentration
1ug per 1ul
-
Antigen Source
KLH conjugated synthetic peptide derived from HPV16 E6 protein
-
Gene ID
1399
-
Applications
IF(IHC-P)
-
Applications with corresponding dilutions
IF(IHC-P)(1:50-200)
-
Cross Reactive species
Virus
-
Cross Reactive Species details
HPV16
-
Background information
Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.
-
Purification method
Purified by Protein G.
-
Storage
Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
-
Excitation emission
590nm/617nm
-
Synonyms
E6; HPV16 E6 protein; Human Papilloma Virus; Human papillomavirus type 16 E6; Human papillomavirus type 16; Protein E6; E6 protein; HPV16 E6; HPV16-E6; VE6_HPV16.
-
Alternative name 1
HPV16 E6 protein (2E3) Monoclonal Antibody, ALEXA FLUOR® 594 Conjugated
-
Alternative name 2
HPV16 E6 protein (2E3) Monoclonal anti-, ALEXA FLUOR 594 Conjugated
-
Advisory
Cycles of freezing and thawing should be avoided as such cycles may denature the peptide chains of the antibody and reduce its affinity, specificity and reactivity. For antibodies in a liquid form or reconstituted lyophilized antibodies - small amounts of the soultion could be captured on the cap or the walls of the container. Right before use you could briefly centrifuge the vial to collect all of the solution on the bottom.
-
Properties
For facs or microscopy Alexa 1 conjugate.
-
Conjugation
Alexa Fluor, ALEXA FLUOR® 594
-
Conjugated
Alexa conjugate 1
-
Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
-
About
Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
-
Gene target
-
Short name
Anti-HPV16 E6 protein (2E3) Monoclonal,
-
Technique
anti-, anti, antibody to, antibodies, Monoclonals or monoclonal antibodies
-
Isotype
Immunoglobulin G (IgG)
-
Label
ALEXA FLUOR 594
-
Alternative name
Antibody toHPV16 E6 protein (2E3) monoclonal, ALEXA Fluor 594
-
Alternative technique
antibodies
-
MeSH Data
-
Name
-
Concept
Scope note:
Methods for detecting or typing the DNA of an ALPHAPAPILLOMAVIRUS in biological tissues and fluids.
-
Tree numbers
- E01.370.225.880.500
- E05.200.880.500
- E05.393.520.750
-
Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Product files
Similar products