HEXA/Beta hexosaminidase subunit alpha Antibody, ALEXA FLUOR 647

• Catalog number
  bs-11726R-A647
• Price
  Please ask
• Size
  100ul

• Long name
  HEXA/Beta hexosaminidase subunit alpha Antibody, ALEXA FLUOR 647 Conjugated
• Also known as
  Anti-HEXA/Beta hexosaminidase subunit alpha PAb ALEXA FLUOR 647
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 647
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  HEXA/Beta hexosaminidase subunit alpha
• Specificity
  This is a highly specific antibody against HEXA/Beta hexosaminidase subunit alpha.
• Modification
  Unmodified
• Modification Site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Beta hexosaminidase subunit alpha
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  Hexosaminidase A (HEXA), also designated beta-Hexosaminidase A, is a trimer composed of one å chain, one ∫-A chain and one ∫-B chain and is found in the lysosomes of cells. HEXA, along with the cofactor CM2 activator protein, catalyzes the degradation of GM2 ganglioside and other molecules containing terminal N-acetyl hexosamines in the brain and other tissues. A mutation in the å subunit of hexosaminidase is the cause of Tay-Sachs disease (TSD), also known as GM2-gangliosidosis type I. TSD is a fatal autosomal recessive lysosomal storage disease of the central nervous system (CNS) caused by insufficient activity of the HEXA enzyme that results in a failure to process GM2 gangliosides. The accumulation of GM2 ganglioside in the absence of HEXA activity causes progressive destruction of the CNS.
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  650nm/665nm
• Synonyms
  Beta hexosaminidase alpha chain precursor; Beta hexosaminidase subunit alpha; Beta N acetylhexosaminidase; Beta N acetylhexosaminidase subunit alpha; Beta-hexosaminidase subunit alpha; Beta-N-acetylhexosaminidase subunit alpha; Hexa; HEXA_HUMAN; Hexosaminidase A alpha polypeptide; Hexosaminidase A alpha polypeptide; Hexosaminidase A; Hexosaminidase subunit A; MGC99608; N acetyl beta glucosaminidase; N acetyl beta glucosaminidase subunit alpha; N-acetyl-beta-glucosaminidase subunit alpha; TSD.
• Properties
  For facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-HEXA/Beta hexosaminidase subunit alpha exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR 647
• Description
  The Anti-HEXA/Beta hexosaminidase subunit alpha is a α- or alpha protein sometimes glycoprotein present in blood.
• French translation
  anticorps

• Gene target
  HEXA/Beta   hexosaminidase   subunit   alpha  
• Gene symbol
  HEXA, HEXA-AS1
• Short name
  Anti-HEXA/Beta hexosaminidase subunit alpha
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 647
• Alternative name
  HEXA/Beta hexosaminidase subunit alpha Antibody, ALEXA FLUOR 647
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:4878
• Gene
  HEXA
• Long gene name
  hexosaminidase subunit alpha
• Synonyms gene name
  • hexosaminidase A (alpha polypeptide)
• Synonyms name
  • Tay Sachs disease
  • GM2 gangliosidosis
  • beta-hexosaminidase subunit alpha
• GenBank acession
  • M13520
• Locus
  15q23
• Discovery year
  2001-06-22
• Entrez gene record
  3073
• Pubmed identfication
  • 2952641
  • 3013851
• RefSeq identity
  • NM_000520
• Classification
  • Hexosaminidases
• VEGA ID
  OTTHUMG00000133445
• Locus Specific Databases
  • Hexosaminidase A; Tay-Sachs Disease
  • ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database

Gene info

• Identity
  HGNC:25810
• Gene
  HEXA-AS1
• Long gene name
  HEXA antisense RNA 1
• Synonyms gene
  • C15orf34
• Synonyms gene name
  • chromosome 15 open reading frame 34
  • HEXA antisense RNA 1 (non-protein coding)
• Synonyms
  • FLJ13315
• Locus
  15q23
• Discovery year
  2005-10-20
• Entrez gene record
  80072
• Pubmed identfication
  • 12477932
• RefSeq identity
  • NR_027262
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000177184

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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