FLT3 (Tyr969) Antibody, ALEXA FLUOR 647
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Catalog numberbs-3151R-A647
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PricePlease ask
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Size100ul
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Long nameFLT3 (Tyr969) Polyclonal Antibody, ALEXA FLUOR 647 Conjugated
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Also known asAnti-FLT3 Tyr969 PAb ALEXA FLUOR 647
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CategoryConjugated Primary Antibodies
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Conjugated withALEXA FLUOR® 647
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Host OrganismRabbit (Oryctolagus cuniculus)
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Target AntigenFLT3 Tyr969
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SpecificityThis is a highly specific antibody against FLT3 Tyr969.
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ModificationPhosphorylation
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Modification SiteTyr969
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ClonalityPolyclonal
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ClonePolyclonal antibody
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Concentration1ug per 1ul
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SourceKLH conjugated synthetic phosphopeptide derived from human FLT3 around the phosphorylation site of Tyr969
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Gene ID Number2322
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Tested applicationsIF(IHC-P)
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Recommended dilutionsIF(IHC-P)(1:50-200)
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CrossreactivityHuman
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Cross reactive species detailsDue to limited amount of testing and knowledge, not every possible cross-reactivity is known.
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Background of the antigenCD135 is a tyrosine kinase receptor expressed on normal cells including CD34+ hematopoietic stem cells, myelomonocytic progenitors, primitive B cell progenitors, and thymocytes. CD135 is also expressed on malignant hematopoietic cells including AML, ALL and CML BC. CD135, also known as FMS-like tyrosine kinase 3, FLT3, STK1, and Flk2, is a growth factor receptor that binds the FLT3 ligand to promote the growth and differentiation of primitive hematopoietic cells. The intracytoplasmic domain of CD135 is modified by phosphorylation and has been shown to interact with Grb2, SOCS1, VAV1, and Shc. In humans, expression of Flt3 is restricted to subsets of CD34 positive as well as CD34 negative normal bone marrow cells. In these cells, the level of expression of Flt3 is rather low. Most of the CD34 bright Flt3+ cells co-express CD117 at high levels. They may represent early cycling, but not quiescent stem cells. Flt3+ cells in the CD34lo and CD34- populations do not co-express CD117 molecule and may represent B lymphoid precursors.
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PurificationPurified by Protein A.
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Storage conditionsStore this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
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Excitation emission650nm/665nm
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SynonymsFlt3 / CD135 phospho Y969; p-Flt3 / CD135 phospho Y969; p-Flt3 phospho Y969; p-CD135 phospho Y969; CD135 antigen; Fetal liver kinase 2; FL cytokine receptor; Flk 2; Flk2; Flt 3; Flt3; FMS like tyrosine kinase 3; Fms related tyrosine kinase 3; Growth factor receptor tyrosine kinase type III; Stem cell tyrosine kinase 1; Stk 1; Stk1; Tyrosine protein kinase receptor FLT3; FLT3_HUMAN.
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PropertiesFor facs or microscopy Alexa 1 conjugate. Alexa Fluor 633 is a practical alternative to APC as well as Cy5. Bioss Primary Conjugated Antibodies. ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode. It is detected in the FL4 detector of the core's upgraded 2-laser FACScans. Like other Alexa Fluor dyes, the Anti-FLT3 Tyr969 exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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ConjugationAlexa Fluor, ALEXA FLUOR 647
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French translationanticorps
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Gene target
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Gene symbolFLT3
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Short nameAnti-FLT3 Tyr969
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeImmunoglobulin G (IgG)
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LabelALEXA FLUOR 647
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Alternative nameFLT3 (Tyr969) Polyclonal Antibody, ALEXA FLUOR 647
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Alternative techniqueantibodies
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Alternative to gene targetfms-related tyrosine kinase 3, CD135 and FLK-2 and FLK2 and STK1, FLT3 and IDBG-19891 and ENSG00000122025 and 2322, transferase activity, nuclei, Flt3 and IDBG-209045 and ENSMUSG00000042817 and 14255, BT.28173 and IDBG-630678 and ENSBTAG00000018572 and 512700
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Gene info
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Identity
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Gene
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Long gene namefms related receptor tyrosine kinase 3
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Synonyms gene name
- fms-related tyrosine kinase 3
- fms related tyrosine kinase 3
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Synonyms
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GenBank acession
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Locus
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Discovery year1990-07-30
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Entrez gene record
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Pubmed identfication
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Classification
- Immunoglobulin like domain containing
- Receptor tyrosine kinases
- CD molecules
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data