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EPO Receptor (Tyr368) Antibody, FITC Conjugated

  • Catalog number
    bs-13087R-FITC
  • Product name
    EPO Receptor (Tyr368) Antibody, FITC Conjugated
  • Size
    0.1ml
  • Price
    350EUR
  • Supplier
    Bioss Primary Conjugated Antibodies
  • Ask
  • Clonality
    Polyclonal
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Antigen background
    The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.
  • Modification site
    Tyr368
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Long name
    EPO Receptor (Tyr368) Antibody, FITC Conjugated
  • Synonyms
    EPO Receptor phospho Y368; p-EPO Receptor phospho Y368; EPOR phospho Y368; p-EPOR phospho Y368; erythropoietin receptor; EPO R; EPO Receptor; Erythropoietin receptor precursor.
  • Gene ID number
    2057
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Conjugation
    FITC
  • Modification
    Phosphorylation
  • Category
    Conjugated Primary Antibodies
  • Source
    KLH conjugated synthetic phosphopeptide derived from human EPO Receptor around the phosphorylation site of Tyr368
  • Specificity
    This is a highly specific antibody against EPO Receptor Tyr368.
  • Tested applications
    IF(IHC-P)
  • Clone
    Polyclonal antibody
  • Crossreactivity
    Human, Mouse, Rat
  • Concentration
    1ug per 1ul
  • Target Antigen
    EPO Receptor Tyr368
  • Excitation Emission
    494nm/518nm
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
  • Additional conjugation
    Anti-FITC Antibody
  • Gene target
  • Short name
    EPO Receptor (Tyr368) Antibody, FITC Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
  • Label
    FITC
  • Alternative name
    erythropoietin Receptor (Tyr368) (Antibody to), fluorecein coupled
  • Alternative technique
    antibodies
  • Alternative to gene target
    erythropoietin, EP and MVCD2, EPO and IDBG-31941 and ENSG00000130427 and 2056, this GO :0001666 and response to hypoxia and biological process this GO :0005128 and erythropoietin receptor binding and molecular function this GO :0005179 and hormone activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007566 and embryo implantation and biological process this GO :0007568 and aging and biological process this GO :0007584 and response to nutrient and biological process this GO :0008015 and blood circulation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009651 and response to salt stress and biological process this GO :0009986 and cell surface and cellular component this GO :0010523 and negative regulation of calcium ion transport into cytosol and biological process this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0030218 and erythrocyte differentiation and biological process this GO :0030295 and protein kinase activator activity and molecular function this GO :0032496 and response to lipopolysaccharide and biological process this GO :0033033 and negative regulation of myeloid cell apoptotic process and biological process this GO :0033189 and response to vitamin A and biological process this GO :0033574 and response to testosterone and biological process this GO :0042523 and positive regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0042541 and hemoglobin biosynthetic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043249 and erythrocyte maturation and biological process this GO :0043627 and response to estrogen and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045740 and positive regulation of DNA replication and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0046579 and positive regulation of Ras protein signal transduction and biological process this GO :0048678 and response to axon injury and biological process this GO :0051602 and response to electrical stimulus and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0061418 and regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0071474 and cellular hyperosmotic response and biological process this GO :1902219 and negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress and biological process this GO :1902251 and negative regulation of erythrocyte apoptotic process and biological process this GO :2001258 and negative regulation of cation channel activity and biological process, protein kinase activator activity, this GO :0005128: erythropoietin receptor binding and also this GO :0005179: hormone activity and also this GO :0005515: protein binding and also this GO :0030295: protein kinase activator activity, this GO :0005128: erythropoietin receptor binding, this GO :0005179: hormone activity, this GO :0005515: protein binding, this GO :0030295: protein kinase activator activity, Extracellular, Epo and IDBG-205003 and ENSMUSG00000029711 and 13856, EPO and IDBG-640493 and ENSBTAG00000003430 and 280784
  • Ask
1. Gene info
MESH Data
  • Name
  • Concept
    Scope note: A method for the study of certain organic compounds within cells, in situ, by measuring the light intensities of the selectively stained areas of cytoplasm. The compounds studied and their locations in the cells are made to fluoresce and are observed under a microscope.
  • Tree numbers
    • E01.370.225.500.386
    • E05.196.712.516.600.240
    • E05.200.500.386
    • E05.242.386
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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