EPO Receptor (Tyr368) Antibody, FITC Conjugated

  • Catalog number
    bs-13087R-FITC
  • Product name
    EPO Receptor (Tyr368) Antibody, FITC Conjugated
  • Size
    0.1ml
  • Price
    413.21
  • Supplier
    Bioss Primary Conjugated Antibodies
  • Long name
    EPO Receptor (Tyr368) Antibody, FITC Conjugated
  • Category
    Conjugated Primary Antibodies
  • Conjugation
    FITC
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    EPO Receptor Tyr368
  • Specificity
    This is a highly specific antibody against EPO Receptor Tyr368.
  • Modification
    Phosphorylation
  • Modification site
    Tyr368
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Concentration
    1ug per 1ul
  • Source
    KLH conjugated synthetic phosphopeptide derived from human EPO Receptor around the phosphorylation site of Tyr368
  • Gene ID number
    2057
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Antigen background
    The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Excitation Emission
    494nm/518nm
  • Synonyms
    EPO Receptor phospho Y368; p-EPO Receptor phospho Y368; EPOR phospho Y368; p-EPOR phospho Y368; erythropoietin receptor; EPO R; EPO Receptor; Erythropoietin receptor precursor.
  • group_crc32
    3233035199
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
  • Additional conjugation
    Anti-FITC Antibody
  • Description
    The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
  • French translation
    anticorps
  • Gene target
  • Short name
    EPO Receptor (Tyr368) Antibody, FITC Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
  • Label
    FITC
  • Alternative name
    erythropoietin Receptor (Tyr368) (Antibody to), fluorecein coupled
  • Alternative technique
    antibodies
  • Alternative to gene target
    erythropoietin, EP and MVCD2, EPO and IDBG-31941 and ENSG00000130427 and 2056, this GO :0001666 and response to hypoxia and biological process this GO :0005128 and erythropoietin receptor binding and molecular function this GO :0005179 and hormone activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0006357 and regulation of transcription from RNA polymerase II promoter and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0007566 and embryo implantation and biological process this GO :0007568 and aging and biological process this GO :0007584 and response to nutrient and biological process this GO :0008015 and blood circulation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009651 and response to salt stress and biological process this GO :0009986 and cell surface and cellular component this GO :0010523 and negative regulation of calcium ion transport into cytosol and biological process this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0030218 and erythrocyte differentiation and biological process this GO :0030295 and protein kinase activator activity and molecular function this GO :0032496 and response to lipopolysaccharide and biological process this GO :0033033 and negative regulation of myeloid cell apoptotic process and biological process this GO :0033189 and response to vitamin A and biological process this GO :0033574 and response to testosterone and biological process this GO :0042523 and positive regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0042541 and hemoglobin biosynthetic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043249 and erythrocyte maturation and biological process this GO :0043627 and response to estrogen and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045740 and positive regulation of DNA replication and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0046579 and positive regulation of Ras protein signal transduction and biological process this GO :0048678 and response to axon injury and biological process this GO :0051602 and response to electrical stimulus and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0061418 and regulation of transcription from RNA polymerase II promoter in response to hypoxia and biological process this GO :0070555 and response to interleukin-1 and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0071474 and cellular hyperosmotic response and biological process this GO :1902219 and negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress and biological process this GO :1902251 and negative regulation of erythrocyte apoptotic process and biological process this GO :2001258 and negative regulation of cation channel activity and biological process, protein kinase activator activity, this GO :0005128: erythropoietin receptor binding and also this GO :0005179: hormone activity and also this GO :0005515: protein binding and also this GO :0030295: protein kinase activator activity, this GO :0005128: erythropoietin receptor binding, this GO :0005179: hormone activity, this GO :0005515: protein binding, this GO :0030295: protein kinase activator activity, Extracellular, Epo and IDBG-205003 and ENSMUSG00000029711 and 13856, EPO and IDBG-640493 and ENSBTAG00000003430 and 280784
MeSH Data
  • Name
  • Concept
    Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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EPO Receptor (Tyr368) Antibody, FITC Conjugated|gentaur.com
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