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EPH receptor A4 Antibody, Cy3 Conjugated

  • Catalog number
    bs-1764R-Cy3
  • Product name
    EPH receptor A4 Antibody, Cy3 Conjugated
  • Size
    0.1ml
  • Price
    350EUR
  • Supplier
    Bioss Primary Conjugated Antibodies
  • Ask
  • Clonality
    Polyclonal
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Antigen background
    Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.
  • Modification site
    None
  • Crossreactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Long name
    EPH receptor A4 Polyclonal Antibody, Cy3 Conjugated
  • Subcellular location
    Cytoplasm
  • Synonyms
    SEK; HEK8; TYRO1; Ephrin type-A receptor 4; EPH-like kinase 8; EK8; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase receptor SEK; EPHA4
  • Gene ID number
    2043
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Purification method
    This antibody was purified via Protein A.
  • Storage conditions
    Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
  • Conjugation
    Cy3
  • Modification
    Unmodified
  • Category
    Conjugated Primary Antibodies
  • Source
    KLH conjugated synthetic peptide derived from human EphA4
  • Swiss Prot
    P54764
  • Specificity
    This is a highly specific antibody against EPH receptor A4.
  • Tested applications
    IF(IHC-P)
  • Clone
    Polyclonal antibody
  • Crossreactivity
    Human, Rat
  • Concentration
    1ug per 1ul
  • Target Antigen
    EPH receptor A4
  • Immunogen_range
    570-620/986
  • Excitation Emission
    512,550nm/570,615nm
  • Properties
    If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the EPH receptor A4 Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
  • Additional conjugation
    cy3 conjugation kit
  • Description
    The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
  • Gene target
  • Short name
    EPH receptor A4 Antibody, Conjugated
  • Technique
    Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
  • Label
    Cy3
  • Alternative name
    EPH receptor A4 (Antibody to), cyanine 3 coupled
  • Alternative technique
    antibodies
  • Ask
1. Gene info
  • Identity
  • Gene
  • Long gene name
    EPH receptor A1
  • Synonyms gene
  • Synonyms gene name
    • EphA1
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1989-05-16
  • Entrez gene record
  • Pubmed identfication
  • Classification
    • Sterile alpha motif domain containing
    • Fibronectin type III domain containing
    • EPH receptors
  • Havana BLAST/BLAT
MESH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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