Dnmt3a Antibody

  • Catalog number
    F40603-0.08ML
  • Price
    Please ask
  • Size
    0.08 ml
  • Category
    Antibody
  • Concentration
    In 1X PBS, pH 7.4, with 0.09% sodium azide
  • Form
    Purified
  • Conjugation
    Unconjugated
  • Clone
    Polyclonal antibody
  • Recognised antigen
    Dnmt3a
  • Host animal
    Rabbit (Oryctolagus cuniculus)
  • Clonality
    Polyclonal (rabbit origin)
  • Species reactivity
    Human (Homo sapiens), Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
  • Tested applications
    WB, IHC, ELISA
  • Recommended dilutions
    Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
  • Notes
    Titration of the Dnmt3a antibody may be required due to differences in protocols and secondary/substrate sensitivity.
  • Intented use
    This Dnmt3a antibodyis to be used only for research purposes and not for diagnostics..
  • Uniprot
    Q9Y6K1
  • Purity
    Purified
  • Description
    Dnmt3a is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. [UniProt]
  • Immunogen
    A portion of amino acids 457-486 from the human protein was used as the immunogen for this Dnmt3a antibody.
  • Storage
    Aliquot the Dnmt3a antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
  • Properties
    If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    Dnmt3a  
  • Gene symbol
    DNMT3A, LINC01381
  • Short name
    Anti-Dnmt3a
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    Rabbit Ig
  • Alternative name
    Antibodies to Dnmt3a
  • Alternative technique
    antibodies
Gene info
  • Identity
  • Gene
  • Long gene name
    DNA methyltransferase 3 alpha
  • Synonyms gene name
    • DNA (cytosine-5-)-methyltransferase 3 alpha
  • Locus
  • Discovery year
    1998-07-15
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • MicroRNA protein coding host genes
    • 7BS C5-cytosine DNA/RNA methyltransferases
    • PWWP domain containing
  • VEGA ID
  • Locus Specific Databases
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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