Desmoglein 2 Antibody

• Catalog number
  R30636
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  Desmoglein 2
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the Desmoglein 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This Desmoglein 2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q14126
• Purity
  Antigen affinity
• Description
  Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines. Mutations in DSG2 display a high degree of penetrance. Disease expression was of variable severity with LV involvement a prominent feature. The low prevalence of classical ECG changes highlights the need to expand current diagnostic criteria to take account of LV disease, childhood disease expression, and incomplete penetrance.
• Immunogen
  An amino acid sequence from the C-terminus of human Desmoglein 2 (STRVTKHSTVQHSYS) was used as the immunogen for this Desmoglein 2 antibody.
• Storage
  After reconstitution, the Desmoglein 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  Desmoglein  
• Gene symbol
  DSG2
• Short name
  Anti-Desmoglein 2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to Desmoglein 2
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3049
• Gene
  DSG2
• Long gene name
  desmoglein 2
• Synonyms
  • CDHF5
• GenBank acession
  • Z26317
• Locus
  18q12.1
• Discovery year
  1991-11-15
• Entrez gene record
  1829
• Pubmed identfication
  • 1612610
• RefSeq identity
  • NM_001943
• Classification
  • Desmosomal cadherins
• VEGA ID
  OTTHUMG00000179649
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_397

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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