CPN2 Antibody, FITC Conjugated

• Catalog number
  bs-9907R-FITC
• Price
  Please ask
• Size
  0.1ml

• Long name
  CPN2 Polyclonal Antibody, FITC Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  FITC
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  CPN2
• Specificity
  This is a highly specific antibody against CPN2.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic peptide derived from human CPN2
• Gene ID number
  1370
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  CPN2 is a zinc metalloprotease, and cleaves carboxy-terminal arginines and lysines from peptides found in the bloodstream such as complement anaphylatoxins, kinins, and creatine kinase MM (CK-MM). By removing only one amino acid, CPN has the ability to change peptide activity and receptor binding. It is a 280 kDa tetrameric glycoprotein that is synthesized by the liver and secreted into the plasma. It consists of 2 identical 83 kDa regulatory subunits (CPN2) and 2 identical 50 kDa catalytic subunits (CPN1). CPN2, the 83 kDa subunit, binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit. CPN is a member of a larger family of carboxypeptidases, many of which also cleave arginine and lysine. Because of the highly conserved active sites and the possible redundant functions of carboxypeptidases, it has been difficult to elucidate the role of CPN in disease processes.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  494nm/518nm
• Synonyms
  CPN 2; CPN2; CPN-2; ACBP; Carboxypeptidase N 83 kDa chain; Carboxypeptidase N large subunit; Carboxypeptidase N regulatory subunit; Carboxypeptidase N subunit 2 [Precursor]; carboxypeptidase N, polypeptide 2; CPN2_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
• Additional conjugation
  Anti-FITC Antibody
• French translation
  anticorps

• Gene target
  CPN2   Conjugated  
• Gene symbol
  CPNE2, CPN2, CYP11B2
• Short name
  Anti-CPN2
• Technique
  Antibody, FITC, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
• Isotype
  Immunoglobulin G (IgG)
• Label
  FITC
• Alternative name
  Anti-CPN2 PAb FITC
• Alternative technique
  antibodies, fluorescine

Gene info

• Identity
  HGNC:2315
• Gene
  CPNE2
• Long gene name
  copine 2
• Synonyms gene name
  • copine II
• Synonyms
  • CPN2
• Locus
  16q13
• Discovery year
  1999-02-09
• Entrez gene record
  221184
• Pubmed identfication
  • 9430674
• RefSeq identity
  • NM_152727
• Classification
  • Copines
• VEGA ID
  OTTHUMG00000133471

Gene info

• Identity
  HGNC:2313
• Gene
  CPN2
• Long gene name
  carboxypeptidase N subunit 2
• Synonyms gene
  • ACBP
• Synonyms gene name
  • carboxypeptidase N, polypeptide 2, 83kD
  • carboxypeptidase N, polypeptide 2
• GenBank acession
  • J05158
• Locus
  3q29
• Discovery year
  1991-08-07
• Entrez gene record
  1370
• Pubmed identfication
  • 2378615
  • 9628828
• RefSeq identity
  • NM_001080513
• Classification
  • M14 carboxypeptidases
• VEGA ID
  OTTHUMG00000156047

Gene info

• Identity
  HGNC:2592
• Gene
  CYP11B2
• Long gene name
  cytochrome P450 family 11 subfamily B member 2
• Synonyms gene
  • CYP11B
• Synonyms gene name
  • cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2
  • cytochrome P450, family 11, subfamily B, polypeptide 2
• Synonyms
  • CYP11BL
  • CPN2
  • P-450C18
  • P450aldo
  • ALDOS
• Synonyms name
  • steroid 11-beta-monooxygenase
• GenBank acession
  • X54741
• Locus
  8q24.3
• Discovery year
  1986-01-01
• Entrez gene record
  1585
• Pubmed identfication
  • 1303253
• Classification
  • Cytochrome P450 family 11
• VEGA ID
  OTTHUMG00000160254

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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