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Target antigen
c Abl
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human
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Analyses
WB
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human c Abl (1020-1049aa ERIASGAITKGVVLDSTEALCLAISRNSEQ), different from the related mouse sequence by one amino acid.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the c Abl Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The c Abl Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
c Abl is also called as ABL1. This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene. Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.
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Related articles
1. "Entrez Gene: ABI1 abl-interactor 1". 2. Biesova Z, Piccoli C, Wong WT (Feb 1997). "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth". Oncogene 14 (2): 233–41. 3. Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim KS, Jenkins EC, Trenkner E, Kotula L (Jul 1998). "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton". J Biol Chem 273 (22): 13681–92.
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Gene Name
ABL1
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Protein Name
Tyrosine-protein kinase ABL1
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Gene Full Name
ABL proto-oncogene 1, non-receptor tyrosine kinase
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Synonyms
Abelson Murine Leukemia Viral Oncogene Homolog 1 antibody|Abelson murine leukemia viral v abl oncogene homolog 1 antibody|Abelson tyrosine protein kinase 1 antibody|Abl 1 antibody| ABL antibody|Abl protein antibody|ABL proto oncogene 1 non receptor tyrosine kinase antibody|Abl1 antibody|ABL1_HUMAN antibody|bcr/abl antibody|Bcr/c abl oncogene protein antibody|c abl oncogene 1 non receptor tyrosine kinase antibody|c abl oncogene 1 receptor tyrosine kinase antibody|JTK 7 antibody|JTK7 antibody|p150 antibody|Proto oncogene tyrosine protein kinase ABL1 antibody|Proto-oncogene c-Abl antibody|Transformation gene oncogene ABL antibody|Tyrosine-protein kinase ABL1 antibody|v abl Abelson murine leukemia viral oncogene homolog 1 antibody|v abl antibody
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Uniprot ID
P00519
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Entrez GeneID
25
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
