BACE1 (Ser498) Antibody, FITC Conjugated

• Catalog number
  bs-5215R-FITC
• Price
  Please ask
• Size
  0.1ml

• Long name
  BACE1 (Ser498) Polyclonal Antibody, FITC Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  FITC
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  BACE1 Ser498
• Specificity
  This is a highly specific antibody against BACE1 Ser498.
• Modification
  Phosphorylation
• Modification site
  Ser498
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human BACE1 around the phosphorylation site of Ser498
• Gene ID number
  23621
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein(APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq].
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  494nm/518nm
• Synonyms
  BACE1 Ser498; BACE1 S498; p-BACE1 Ser498; p-BACE1 Se498; APP beta secretase; Asp 2; ASP2; Aspartyl protease 2; BACE 1; BACE; Beta secretase 1; Beta secretase; Beta site amyloid beta A4 precursor protein cleaving enzyme; Beta site amyloid precursor protein cleaving enzyme 1; Beta site amyloid precursor protein cleaving enzyme; Beta site APP cleaving enzyme 1; Beta site APP cleaving enzyme; FLJ90568; HSPC104; KIAA1149; Memapsin-2; Memapsin 2; Memapsin2; Membrane associated aspartic protease 2; Transmembrane aspartic proteinase Asp2; BACE1_HUMAN; Beta-secretase 1; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Membrane-associated aspartic protease 2.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
• Additional conjugation
  Anti-FITC Antibody
• French translation
  anticorps

• Gene target
  BACE1   Ser498   Conjugated  
• Gene symbol
  BACE1, BACE1-AS
• Short name
  Anti-BACE1 Ser498
• Technique
  Antibody, FITC, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
• Isotype
  Immunoglobulin G (IgG)
• Label
  FITC
• Alternative name
  Anti-BACE1 Ser498 PAb FITC
• Alternative technique
  antibodies, fluorescine

Gene info

• Identity
  HGNC:933
• Gene
  BACE1
• Long gene name
  beta-secretase 1
• Synonyms gene
  • BACE
• Synonyms gene name
  • beta-site APP-cleaving enzyme
  • beta-site APP-cleaving enzyme 1
• GenBank acession
  • AF190725
• Locus
  11q23.3
• Discovery year
  1999-10-29
• Entrez gene record
  23621
• Pubmed identfication
  • 10531052
• Classification
  • Peptidase family A1
• VEGA ID
  OTTHUMG00000160636

Gene info

• Identity
  HGNC:37125
• Gene
  BACE1-AS
• Long gene name
  BACE1 antisense RNA
• Synonyms gene
  • BACE1AS
• Synonyms gene name
  • BACE1 antisense RNA (non-protein coding)
• Synonyms
  • FJ573250
  • NCRNA00177
  • BACE1-AS1
• Synonyms name
  • non-protein coding RNA 177
• Locus
  11q23.3
• Discovery year
  2009-07-15
• Entrez gene record
  100379571
• Pubmed identfication
  • 18587408
  • 21785702
• RefSeq identity
  • NR_037803
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000188154

MeSH Data

• Name
  Fluorescent Antibody Technique
• Concept
  Scope note: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
• Tree numbers
  • E01.370.225.500.607.512.240
  • E01.370.225.750.551.512.240
  • E05.200.500.607.512.240
  • E05.200.750.551.512.240
  • E05.478.583.375
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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