Antithrombin (Native Protein)
Inhibitor of serine proteases, Member of Serpin Family
Antithrombin is the most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
Research area interests
Diseases associated with SERPINC1 include Thrombophilia Due To Antithrombin Iii Deficiency and Disseminated Intravascular Coagulation. Among its related pathways are Platelet activation, signaling and aggregation and Formation of Fibrin Clot (Clotting Cascade).
inhibitor of proteases
Serpin Family C Member 1, SERPINC1
Available target modification
20 mM sodium phospahte buffer pH7.4; 250 mM NaCl without BSA and Azide, free of heparin
serpin family C member 1
Purified from human serum.
Mentioned in the data sheet
See the data sheet
For Research Use only.
cool packs or dry ice
Store at -70°C
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Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Gene ontology - Cellular component
Gene ontology - Biological process
Gene ontology - Molecular function