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anti-SIRT1 Antibody

  • Catalog number
    6137-100
  • Product name
    anti-SIRT1 Antibody
  • Size
    SIRT1 Antibody
  • Price
    414EUR
  • Supplier
    biovision antibodies-kits-proteins
  • Antibody host:
    Rabbit
  • This antibody reacts with:
    Human, mouse, rat
  • Purification method:
    Affinity purified
  • Immunogene sequence:
    C terminal peptide of human SIRT1
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Form of antibody:
    Liquid
  • This antibody has been succesfully tested for use in following methods:
    Western blot, Immunohistochemistry
  • Target of this antibody:
    SIRT1
  • Formulation of this antibody:
    100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
  • Alternative names of antibody target:
    SIRT1, SIR2L1
  • Recommended usage:
    Western blot: 1:500 – 1:2000 dilution, IHC: 1:50 - 1:200 dilution. However, the optimal conditions should be determined individually.
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • Clonality of antibody:
    Polyclonal
  • Isotype:
    Rabbit IgG
  • Background information:
    The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. This SIRT family of genes is highly conserved from prokaryotes to eukaryotes and is involved in diverse processes including transcriptional regulation, cell cycle progression, DNA damage repair and aging. SIRT1 has been shown to be induced by caloric restriction (CR) in several tissues and SIRT1 mediated deacetylase activity attenuates B-amyloid content in the brain during CR. SIRT1 also regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53.
  • Concentration of antibody:
    N/A
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by biovision antibodies-kits-proteins they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Gene target
  • Short name
    anti-SIRT1 Antibody
  • Technique
    Antibody, antibody to, antibodies against human proteins, antibodies for
  • Alternative name
    antibody to-sirtuin 1 (Antibody to)
  • Alternative technique
    antibodies
  • Alternative to gene target
    sirtuin 1, SIR2L1, SIRT1 and IDBG-75847 and ENSG00000096717 and 23411, this GO :0000012 and single strand break repair and biological process this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0000183 and chromatin silencing at rDNA and biological process this GO :0000720 and pyrimidine dimer repair by nucleotide-excision repair and biological process this GO :0000731 and DNA synthesis involved in DNA repair and biological process this GO :0000790 and nuclear chromatin and cellular component this GO :0001525 and angiogenesis and biological process this GO :0001542 and ovulation from ovarian follicle and biological process this GO :0001678 and cellular glucose homeostasis and biological process this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002039 and p53 binding and molecular function this GO :0002821 and positive regulation of adaptive immune response and biological process this GO :0003714 and transcription corepressor activity and molecular function this GO :0004407 and histone deacetylase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005635 and nuclear envelope and cellular component this GO :0005637 and nuclear inner membrane and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005677 and chromatin silencing complex and cellular component this GO :0005719 and nuclear euchromatin and cellular component this GO :0005720 and nuclear heterochromatin and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0006260 and DNA replication and biological process this GO :0006281 and DNA repair and biological process this GO :0006325 and chromatin organization and biological process this GO :0006342 and chromatin silencing and biological process this GO :0006343 and establishment of chromatin silencing and biological process this GO :0006344 and maintenance of chromatin silencing and biological process this GO :0006346 and methylation-dependent chromatin silencing and biological process this GO :0006351 and transcription, DNA-templated and biological process this GO :0006364 and rRNA processing and biological process this GO :0006476 and protein deacetylation and biological process this GO :0006642 and triglyceride mobilization and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007346 and regulation of mitotic cell cycle and biological process this GO :0007517 and muscle organ development and biological process this GO :0007569 and cell aging and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0008134 and transcription factor binding and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0009267 and cellular response to starvation and biological process this GO :0010875 and positive regulation of cholesterol efflux and biological process this GO :0010906 and regulation of glucose metabolic process and biological process this GO :0016032 and viral process and biological process this GO :0016239 and positive regulation of macroautophagy and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0016575 and histone deacetylation and biological process this GO :0016605 and PML body and cellular component this GO :0017136 and NAD-dependent histone deacetylase activity and molecular function this GO :0018394 and peptidyl-lysine acetylation and biological process this GO :0019213 and deacetylase activity and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0030308 and negative regulation of cell growth and biological process this GO :0030512 and negative regulation of transforming growth factor beta receptor signaling pathway and biological process this GO :0031393 and negative regulation of prostaglandin biosynthetic process and biological process this GO :0031648 and protein destabilization and biological process this GO :0031667 and response to nutrient levels and biological process this GO :0031937 and positive regulation of chromatin silencing and biological process this GO :0032007 and negative regulation of TOR signaling and biological process this GO :0032071 and regulation of endodeoxyribonuclease activity and biological process this GO :0032088 and negative regulation of NF-kappaB transcription factor activity and biological process this GO :0032868 and response to insulin and biological process this GO :0033158 and regulation of protein import into nucleus, translocation and biological process this GO :0033553 and rDNA heterochromatin and cellular component this GO :0033558 and protein deacetylase activity and molecular function this GO :0034391 and regulation of smooth muscle cell apoptotic process and biological process this GO :0034979 and NAD-dependent protein deacetylase activity and molecular function this GO :0034983 and peptidyl-lysine deacetylation and biological process this GO :0035098 and ESC/E(Z) complex and cellular component this GO :0035356 and cellular triglyceride homeostasis and biological process this GO :0035358 and regulation of peroxisome proliferator activated receptor signaling pathway and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042326 and negative regulation of phosphorylation and biological process this GO :0042393 and histone binding and molecular function this GO :0042542 and response to hydrogen peroxide and biological process this GO :0042632 and cholesterol homeostasis and biological process this GO :0042771 and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :0042802 and identical protein binding and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043124 and negative regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043161 and proteasome-mediated ubiquitin-dependent protein catabolic process and biological process this GO :0043280 and positive regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043398 and HLH domain binding and molecular function this GO :0043425 and bHLH transcription factor binding and molecular function this GO :0043433 and negative regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0043518 and negative regulation of DNA damage response, signal transduction by p53 class mediator and biological process this GO :0045087 and innate immune response and biological process this GO :0045348 and positive regulation of MHC class II biosynthetic process and biological process this GO :0045599 and negative regulation of fat cell differentiation and biological process this GO :0045739 and positive regulation of DNA repair and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046628 and positive regulation of insulin receptor signaling pathway and biological process this GO :0046872 and metal ion binding and molecular function this GO :0046969 and NAD-dependent histone deacetylase activity (H3-K9 specific) and molecular function this GO :0050872 and white fat cell differentiation and biological process this GO :0051019 and mitogen-activated protein kinase binding and molecular function this GO :0051097 and negative regulation of helicase activity and biological process this GO :0051574 and positive regulation of histone H3-K9 methylation and biological process this GO :0051898 and negative regulation of protein kinase B signaling and biological process this GO :0055089 and fatty acid homeostasis and biological process this GO :0060766 and negative regulation of androgen receptor signaling pathway and biological process this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0070403 and NAD+ binding and molecular function this GO :0070857 and regulation of bile acid biosynthetic process and biological process this GO :0070932 and histone H3 deacetylation and biological process this GO :0071356 and cellular response to tumor necrosis factor and biological process this GO :0071456 and cellular response to hypoxia and biological process this GO :0071479 and cellular response to ionizing radiation and biological process this GO :1901215 and negative regulation of neuron death and biological process this GO :1902166 and negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :1902176 and negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway and biological process this GO :1990254 and keratin filament binding and molecular function this GO :2000111 and positive regulation of macrophage apoptotic process and biological process this GO :2000480 and negative regulation of cAMP-dependent protein kinase activity and biological process this GO :2000481 and positive regulation of cAMP-dependent protein kinase activity and biological process this GO :2000655 and negative regulation of cellular response to testosterone stimulus and biological process this GO :2000757 and negative regulation of peptidyl-lysine acetylation and biological process this GO :2000773 and negative regulation of cellular senescence and biological process this GO :2000774 and positive regulation of cellular senescence and biological process, keratin filament binding, this GO :0002039: p53 binding and also this GO :0003714: transcription corepressor activity and also this GO :0004407: histone deacetylase activity and also this GO :0005515: protein binding and also this GO :0008022: protein C-terminus binding and also this GO :0008134: transcription factor binding and also this GO :0017136: NAD-dependent histone deacetylase activity and also this GO :0019213: deacetylase activity and also this GO :0019899: enzyme binding and also this GO :0033558: protein deacetylase activity and also this GO :0034979: NAD-dependent protein deacetylase activity and also this GO :0042393: histone binding and also this GO :0042802: identical protein binding and also this GO :0043398: HLH domain binding and also this GO :0043425: bHLH transcription factor binding and also this GO :0046872: metal ion binding and also this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific) and also this GO :0051019: mitogen-activated protein kinase binding and also this GO :0070403: NAD+ binding and also this GO :1990254: keratin filament binding, this GO :0002039: p53 binding, this GO :0003714: transcription corepressor activity, this GO :0004407: histone deacetylase activity, this GO :0005515: protein binding, this GO :0008022: protein C-terminus binding, this GO :0008134: transcription factor binding, this GO :0017136: NAD-dependent histone deacetylase activity, this GO :0019213: deacetylase activity, this GO :0019899: enzyme binding, this GO :0033558: protein deacetylase activity, this GO :0034979: NAD-dependent protein deacetylase activity, this GO :0042393: histone binding, this GO :0042802: identical protein binding, this GO :0043398: HLH domain binding, this GO :0043425: bHLH transcription factor binding, this GO :0046872: metal ion binding, this GO :0046969: NAD-dependent histone deacetylase activity (H3-K9 specific), this GO :0051019: mitogen-activated protein kinase binding, this GO :0070403: NAD+ binding, this GO :1990254: keratin filament binding, nuclei, Sirt1 and IDBG-159441 and ENSMUSG00000020063 and 93759, SIRT1 and IDBG-629119 and ENSBTAG00000014023 and 613629
1. Gene info
  • Identity
  • Gene
  • Long gene name
    sirtuin 1
  • Synonyms gene name
    • sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1
    • sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2001-03-20
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Sirtuins
  • Havana BLAST/BLAT
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