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Gene info
p53DINP1 Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible gene was identified recently and designated p53DINP1 (for p53-dependent damage-inducible nuclear protein 1) and SIP (for stress induced protein) in human and mouse. A p53DINP1 antisense oligonucleotide inhibits and overexpression of p53DINP1 enhances Ser46 phosphorylation of p53, induction of p53AIP1, and cell death induced by DNA double-strand breaks. p53DINP1 may regulate p53-dependent apoptosis through phosphorylation at Ser46 and induction of p53AIP1. The p53DINP1/SIP gene encodes two proteins of 27 and 18 kDa in human and mouse termed p53DINP1-alpha and p53DINP1-beta or SIP27 and SIP18. p53DINP1/SIP is expressed in many tissues and induced by a variety of stress agents including UV stress, mutagenic stress, heat shock, and oxidative stress.
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Gene names
p53DINP1 Antibody: SIP, Teap, p53DINP1, TP53DINP1, TP53INP1A, TP53INP1B, P53DINP1, SIP, Tumor protein p53-inducible nuclear protein 1, Stress-induced protein
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Antibodie s label
unlabelled serum
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Purity
p53DINP1 Antibody is affinity chromatography purified via peptide column.
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Ab raised in
Rabbit
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Type
Polyclonal
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Immunoglobulin
IgG
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Spicific to
A lower band at 18 kDa was detected in human spleen, and mouse liver and kidney tissue lysates, which may represent the p53DINP1-b form.
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Antigen
p53DINP1 antibody was made with a synthetic peptide corresponding to 14 amino acids near the amino terminus of human p53DINP1.
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Immuno application
ELISA, Western Blot, immuno-histo-chemistry
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Antibody advice
p53DINP1 antibody can be used for detection of p53DINP1 by Western blot at 0.5 - 1 ug/mL. A band at 27 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 2 ug/mL.
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Suspention pH azide
p53DINP1 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep at
p53DINP1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works with
Human, Mouse, Rat
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Omim nr
61216823
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Ncbi nr
Q96A56
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KDa
27 kDa
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
94241
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GENE symbol
TP53INP1
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Antigene name
tumor protein p53 inducible nuclear protein 1
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Source
Homo sapiens
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Protein nr
Q96A56
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
