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anti-p53 Antibody (Clone C6A5)

  • Catalog number
    3036-100
  • Product name
    anti-p53 Antibody (Clone C6A5)
  • Size
    p53 Antibody (Clone C6A5)
  • Price
    371EUR
  • Supplier
    biovision antibodies-kits-proteins
  • Antibody host:
    Mouse
  • This antibody reacts with:
    Human, mouse, rat
  • Purification method:
    Affinity purified
  • Immunogene sequence:
    Synthetic peptide corresponding to residue surrounding Ser20 of human p53
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Form of antibody:
    Liquid
  • This antibody has been succesfully tested for use in following methods:
    Western blot, Immunoprecipitation, Immunohistochemistry, Immunocytochemistry
  • Target of this antibody:
    p53
  • Formulation of this antibody:
    100 µg (0.5 mg/ml) in PBS containing 1 mg/ml BSA and 1.5 mM sodium azide and 50% glycerol.
  • Alternative names of antibody target:
    TP53, TRP53, P53, LFS1, Tumor suppressor p53, Phosphoprotein p53
  • Recommended usage:
    Western blotting (0.5-4 µg/ml), immunoprecipitation (4-8 µg/ml), Immunohistochemistry (4-8 µg/ml), immunocytochemistry (4-8 µg/ml). However, the optimal conditions should be determined individually.
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • Clonality of antibody:
    Monoclonal
  • Isotype:
    Mouse IgG1
  • Clone:
    C6A5
  • Background information:
    p53, a 53 kDa protein, binds to a DNA consensus sequence, the p53 response element, and regulates normal cell cycle events by activating transcription of genes involved either in progression throμgh the cell cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the concentration in normal cells, principally due to the increased half-life (4 hrs) compared to that of wild-type (20 min). p53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and certain mutations also modulate cytoplasmic/nuclear distribution. p53 downregulates Bcl-2 expression and upregulates Bax expression, but may not always be necessary for apoptosis.
  • Concentration of antibody:
    0.5 mg/ml
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by biovision antibodies-kits-proteins they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Gene target
  • Short name
    anti-p53 Antibody (Clone C6A5)
  • Technique
    Antibody, antibody to, antibodies against human proteins, antibodies for
  • Alternative name
    antibody to-p53 (Antibody to) (clonality C6A5)
  • Alternative technique
    antibodies
  • Clone name
    C6A5
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