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Gene info
NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-k-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-k-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.
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Gene names
p52, p105, H2TF1, LYT10, CVID10, LYT-10, NF-kB2, EIF4F, EIF4G, EIF4GI, DNA-binding factor KBF2, Lymphocyte translocation chromosome 10, Lyt10, NFKB2
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Antibodie s label
unlabelled serum
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Purity
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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Ab raised in
Rabbit
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Type
Polyclonal
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Spicific to
This antibody detects endogenous level of total NFkB-p100/p52 protein.
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Antigen
NFkB-p100/p52 (Ab-866) antibody was made against a peptide sequence around aa.864~868 (E-D-S-A-Y) derived from Human NFkB-p100/p52.
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Immuno application
Western Blot, immuno-histo-chemistry, immuno fluorescence
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Antibody advice
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
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Suspention pH azide
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Keep at
Store antibody at -20 grades C for up to one year.
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Works with
Human, Mouse, Rat
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Omim nr
117320540
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Ncbi nr
NP_001070961.1
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KDa
120 kDa
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Vial with antibody
in solution
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Quantity per ml
1 mg/mL
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NCBI GENE nr
4791
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GENE symbol
NFKB2
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Antigene name
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
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Source
Homo sapiens
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Protein nr
Q00653
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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Properties
If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Gene
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory
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French translation
anticorps
