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anti-MSH6 Antibody

  • Catalog number
    3879-100
  • Product name
    anti-MSH6 Antibody
  • Size
    MSH6 Antibody
  • Price
    316EUR
  • Supplier
    biovision antibodies-kits-proteins
  • Antibody host:
    Rabbit
  • This antibody reacts with:
    Human
  • Purification method:
    Affinity purified
  • Immunogene sequence:
    Synthetic peptide of human MSH6
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Form of antibody:
    Liquid
  • This antibody has been succesfully tested for use in following methods:
    Western blot
  • Target of this antibody:
    MSH6
  • Formulation of this antibody:
    100 µL affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
  • Alternative names of antibody target:
    MSH-6, MSH 6, DNA mismatch repair protein Msh6, G/T mismatch-binding protein, GTMBP, GTBP , mutS (E. coli) homolog 6, HNPCC 5, HNPCC5, MSH 6, MSH6
  • Recommended usage:
    Western blotting (1:500 to 1:2000). However, the optimal concentrations should be determined individually. TK6 cell lysate can be used as a positive control. The antibody recognizes human MSH6. Reactivity to other species has not been tested.
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • Clonality of antibody:
    Polyclonal
  • Isotype:
    Rabbit IgG
  • Background information:
    The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between nonidentical DNA sequences, and induces both checkpoint and apoptotic responses following certain types of DNA damage. MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins, and the Rad50-Mre11-NBS1 complex. Mutations in MSH6 and other MMR proteins have been found in a large proportion of hereditary nonpolyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world. Mutations in MSH6 have been shown to occur in glioblastoma in response to temozolomide therapy and to promote temozolomide resistance.
  • Concentration of antibody:
    0.5 mg/ml
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by biovision antibodies-kits-proteins they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Gene target
  • Short name
    anti-MSH6 Antibody
  • Technique
    Antibody, antibody to, antibodies against human proteins, antibodies for
  • Alternative name
    antibody to-mutS homolog 6 (E. coli) (Antibody to)
  • Alternative technique
    antibodies
  • Alternative to gene target
    mutS homolog 6 (E. coli), GTBP and GTMBP and HNPCC5 and HSAP and p160, MSH6 and IDBG-51044 and ENSG00000116062 and 2956, this GO :0000228 and nuclear chromosome and cellular component this GO :0000287 and magnesium ion binding and molecular function this GO :0000400 and four-way junction DNA binding and molecular function this GO :0000710 and meiotic mismatch repair and biological process this GO :0000790 and nuclear chromatin and cellular component this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003684 and damaged DNA binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006281 and DNA repair and biological process this GO :0006298 and mismatch repair and biological process this GO :0007131 and reciprocal meiotic recombination and biological process this GO :0008094 and DNA-dependent ATPase activity and molecular function this GO :0008340 and determination of adult lifespan and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0009411 and response to UV and biological process this GO :0016446 and somatic hypermutation of immunoglobulin genes and biological process this GO :0016447 and somatic recombination of immunoglobulin gene segments and biological process this GO :0016887 and ATPase activity and molecular function this GO :0030983 and mismatched DNA binding and molecular function this GO :0032137 and guanine/thymine mispair binding and molecular function this GO :0032142 and single guanine insertion binding and molecular function this GO :0032143 and single thymine insertion binding and molecular function this GO :0032301 and MutSalpha complex and cellular component this GO :0032357 and oxidized purine DNA binding and molecular function this GO :0032405 and MutLalpha complex binding and molecular function this GO :0035064 and methylated histone binding and molecular function this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043531 and ADP binding and molecular function this GO :0045190 and isotype switching and biological process this GO :0045910 and negative regulation of DNA recombination and biological process this GO :0051096 and positive regulation of helicase activity and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process, ADP binding, this GO :0000287: magnesium ion binding and also this GO :0000400: four-way junction DNA binding and also this GO :0003677: DNA binding and also this GO :0003682: chromatin binding and also this GO :0003684: damaged DNA binding and also this GO :0003690: double-stranded DNA binding and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0008094: DNA-dependent ATPase activity and also this GO :0016887: ATPase activity and also this GO :0030983: mismatched DNA binding and also this GO :0032137: guanine/thymine mispair binding and also this GO :0032142: single guanine insertion binding and also this GO :0032143: single thymine insertion binding and also this GO :0032357: oxidized purine DNA binding and also this GO :0032405: MutLalpha complex binding and also this GO :0035064: methylated histone binding and also this GO :0043531: ADP binding, this GO :0000287: magnesium ion binding, this GO :0000400: four-way junction DNA binding, this GO :0003677: DNA binding, this GO :0003682: chromatin binding, this GO :0003684: damaged DNA binding, this GO :0003690: double-stranded DNA binding, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0008094: DNA-dependent ATPase activity, this GO :0016887: ATPase activity, this GO :0030983: mismatched DNA binding, this GO :0032137: guanine/thymine mispair binding, this GO :0032142: single guanine insertion binding, this GO :0032143: single thymine insertion binding, this GO :0032357: oxidized purine DNA binding, this GO :0032405: MutLalpha complex binding, this GO :0035064: methylated histone binding, this GO :0043531: ADP binding, nuclei, Msh6 and IDBG-201548 and ENSMUSG00000005370 and 17688, BT.98842 and IDBG-633641 and ENSBTAG00000001424 and 540526
1. Gene info
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