anti-MADD Antibody

• Catalog number
  1150
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  MADD Antibody: MAP kinase-activating death domain protein (MADD) was initially identified as the type 1 tumor necrosis factor receptor (TNFR1) associated protein though their death domains. Overexpression of MADD activates MAP kinases ERK and JNK and induces the phosphorylation of cytosolic phospholipase A2. MADD shares 98% identity with DENN (for differentially expressed in neoplastic vs. normal cells), which was recently identified as a substrate for c-jun N-terminal kinase 3 (JNK3). MADD has greater than 94% overall identity to a GDP/GTP exchange protein Rab3-GEP. MADD is 87% identical to KIAA0358, a brain protein of unknown function. Identification of MADD as a component of the TNFR1 signaling complex and the similarity between MADD and Rab3-GEP provides a connection between TNFR1 activation and downstream MAP kinase activity through a guanine-nucleotide exchange protein.
• Gene names
  MADD Antibody: DENN, IG20, RAB3GEP, DENN, KIAA0358, MAP kinase-activating death domain protein, Differentially expressed in normal and neoplastic cells
• Antibodie s label
  unlabelled serum
• Purity
  MADD Antibody is Antibody is DEAE purified.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  MADD antibody was made against a peptide corresponding to amino acids near the carboxy terminus of human MADD.
• Immuno application
  ELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence
• Antibody advice
  MADD antibody can be used for detection of MADD by Western blot at 1 - 2 mg/mL. 200 to 220 kDa bands should be detected. Antibody can also be used for immunocytochemistry starting at 10 ug/mL. For immunofluorescence start at 20 ug/mL.
• Suspention pH azide
  MADD Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  MADD antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  3289973
• Ncbi nr
  AAD12154
• KDa
  200 to 220 kDa
• Vial with antibody
  in solution
• NCBI GENE nr
  8567
• GENE symbol
  MADD
• Antigene name
  MAP-kinase activating death domain
• Source
  Homo sapiens
• Protein nr
  Q8WXG6
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  MADD  
• Gene symbol
  MADD-AS1, MADD, ETFA
• Short name
  anti-MADD Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toMADD (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  MAP-kinase activating death domain, DENN and IG20 and RAB3GEP, MADD and IDBG-42977 and ENSG00000110514 and 8567, protein kinase activator activity, Plasma membranes, Madd and IDBG-190319 and ENSMUSG00000040687 and 228355, MADD and IDBG-637361 and ENSBTAG00000021700 and 534306

Gene info

• Identity
  HGNC:40354
• Gene
  MADD-AS1
• Long gene name
  MADD antisense RNA 1
• Locus
  11p11.2
• Discovery year
  2019-08-16
• Entrez gene record
  101928943
• RefSeq identity
  • NR_120568
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:6766
• Gene
  MADD
• Long gene name
  MAP kinase activating death domain
• Synonyms gene name
  • MAP-kinase activating death domain
• Synonyms
  • DENN
  • KIAA0358
  • RAB3GEP
• GenBank acession
  • AB002356
• Locus
  11p11.2
• Discovery year
  1999-12-17
• Entrez gene record
  8567
• Pubmed identfication
  • 9115275
  • 9796103
• Classification
  • DENN domain containing
• VEGA ID
  OTTHUMG00000150350

Gene info

• Identity
  HGNC:3481
• Gene
  ETFA
• Long gene name
  electron transfer flavoprotein subunit alpha
• Synonyms gene name
  • electron-transfer-flavoprotein, alpha polypeptide
• Synonyms
  • GA2
  • EMA
  • MADD
• Synonyms name
  • glutaric aciduria II
• GenBank acession
  • J04058
• Locus
  15q24.2-q24.3
• Discovery year
  1986-01-01
• Entrez gene record
  2108
• RefSeq identity
  • NM_000126
• VEGA ID
  OTTHUMG00000172586

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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