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anti-HdmX/MDM4 Antibody

  • Catalog number
    3762-100
  • Product name
    anti-HdmX/MDM4 Antibody
  • Size
    HdmX/MDM4 Antibody
  • Price
    338EUR
  • Supplier
    biovision antibodies-kits-proteins
  • Antibody host:
    Rabbit
  • This antibody reacts with:
    Human
  • Purification method:
    Affinity purified
  • Immunogene sequence:
    Synthetic peptide of human HmdX/MDM4
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Form of antibody:
    Liquid
  • This antibody has been succesfully tested for use in following methods:
    Western blot, Immunoprecipitation
  • Target of this antibody:
    HdmX/MDM4
  • Formulation of this antibody:
    100 µl affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 1% BSA and 0.02% thimerosal.
  • Alternative names of antibody target:
    HdmX, MdmX, MDM4, homolog of mouse double minute 4 protein
  • Recommended usage:
    Western blotting (1:500 – 1:1500) and Immunoprecipitation. MCF7 cell lysate can be used as a positive control. However, the optimal concentrations should be determined individually. The antibody recognizes the HdmX/MDM4 of human origin. Reactivity to other species has not been tested.
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • Clonality of antibody:
    Polyclonal
  • Isotype:
    Rabbit IgG
  • Background information:
    The MDM2 protein is the primary regulator of p53 protein stability. MDMX is an MDM2-related protein that inhibits MDM2-mediated degradation of p53 via distinct associations with MDM2. The gene that encodes MDMX (also designated MDM4) is a target for amplification in malignant gliomas. ARF interacts with MDMX to sequester MDMX within the nucleolus. This sequestration of MDMX by ARF results in an increase in p53 transactivation. In addition, expression of MDMX can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation. Like MDM2, MDMX also binds p73 and stabilizes the level of p73. Therefore, in striking contrast to p53, the half-life of p73 is increased by binding to MDM2.
  • Concentration of antibody:
    N/A
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Properties
    If you buy Antibodies supplied by biovision antibodies-kits-proteins they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Gene target
  • Short name
    anti-HdmX/MDM4 Antibody
  • Technique
    Antibody, antibody to, antibodies against human proteins, antibodies for
  • Alternative name
    antibody to-HdmX/Mdm4 p53 binding protein homolog (mouse) (Antibody to)
  • Alternative technique
    antibodies
  • Alternative to gene target
    Mdm4 p53 binding protein homolog (mouse), HDMX and MDMX and MRP1, MDM4 and IDBG-106054 and ENSG00000198625 and 4194, this GO :0000122 and negative regulation of transcription from RNA polymerase II promoter and biological process this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006461 and protein complex assembly and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0008283 and cell proliferation and biological process this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0019899 and enzyme binding and molecular function this GO :0030330 and DNA damage response, signal transduction by p53 class mediator and biological process this GO :0042177 and negative regulation of protein catabolic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045023 and G0 to G1 transition and biological process this GO :0050821 and protein stabilization and biological process this GO :0071157 and negative regulation of cell cycle arrest and biological process this GO :0071456 and cellular response to hypoxia and biological process, enzyme binding, this GO :0005515: protein binding and also this GO :0008270: zinc ion binding and also this GO :0019899: enzyme binding, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, this GO :0019899: enzyme binding, nuclei, Mdm4 and IDBG-192393 and ENSMUSG00000054387 and 102641776,17248, BT.36413 and IDBG-628663 and ENSBTAG00000006255 and 100138492,514225
1. Gene info
  • Identity
  • Gene
  • Long gene name
    MDM4, p53 regulator
  • Synonyms gene name
    • mouse double minute 4, human homolog of; p53-binding protein
    • Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)
    • Mdm4 p53 binding protein homolog (mouse)
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1997-09-05
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Havana BLAST/BLAT
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