FOXP3 Antibody
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Catalog numberRP1032
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PricePlease ask
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Size0,1 mg
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Target antigenFOXP3
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ClonalityPolyclonal antibody
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ClonePolyclonal antibody
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Raised inrabbit
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Type of the antibodyIgG polyclonal antibody
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Product formfreeze-dried
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Reacts with specieshuman
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AnalysesIHC-P
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ImmunogenE.coli-derived human FOXP3 recombinant protein (Position: H101-P431). Human FOXP3 shares 88% amino acid (aa) sequence identity with mouse FOXP3.
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Product configurationEach vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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PurificationImmunogen affinity purified.
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SolubilizationThe powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtionsKeep the FOXP3 Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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TipsThe FOXP3 Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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BackgroundFOXP3(forkhead box P3) is a protein involved in immune system responses. The human FOXP3 genes contain 11 coding exons. Exon-intron boundaries are identical across the coding regions of the mouse and human genes. By genomic sequence analysis, the FOXP3 gene maps to the p arm of the X chromosome(specifically, Xp11.23). A member of the FOX protein family, FOXP3 appears to function as a master regulator in the development and function of regulatory T cells. While the precise control mechanism has not yet been established, FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription.
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Related articles1. Allan, S. E., Passerini, L., Bacchetta, R., Crellin, N., Dai, M., Orban, P. C., Ziegler, S. F., Roncarolo, M. G., Levings, M. K.The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.J. Clin. Invest. 115: 3276-3284, 2005. 2. Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E., Saulsbury, F. T., Chance, P. F., Ochs, H. D.The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.Nature Genet. 27: 20-21, 2001. 3. Hong, J., Li, N., Zhang, X., Zheng, B., Zhang, J. Z.Induction of CD4+CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3.Proc. Nat. Acad. Sci. 102: 6449-6454, 2005.
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Gene NameFOXP3
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Protein NameForkhead box protein P3
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Gene Full Nameforkhead box P3
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SynonymsAIID antibody|DIETER antibody|Forkhead box P3 antibody|Forkhead box protein P3 antibody|foxp3 antibody|FOXP3_HUMAN antibody|FOXP3delta7 antibody|Immune dysregulation polyendocrinopathy enteropathy X linked antibody|Immunodeficiency polyendocrinopathy enteropathy X linked antibody|IPEX antibody|JM2 antibody|MGC141961 antibody|MGC141963 antibody|OTTHUMP00000025832 antibody|OTTHUMP00000025833 antibody|OTTHUMP00000226737 antibody|PIDX antibody|SCURFIN antibody|XPID antibody
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Uniprot IDQ9BZS1
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Entrez GeneID50943
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PropertiesIf you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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GeneForkhead Box Protein P3 scurfin FOXP3, is a protein involved in immune system responses. A member of the FOX protein family, FOXP3 appears to function as a master regulator of the regulatory pathway in the development and function of regulatory T cells. Foxp3 or forkhead box P3 or skurfin or scurfin or skurfina is also known as IPEX, AIID, PIDX, XPID and DIETER.
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French translationanticorps
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Gene target
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Gene symbolFOXP3
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Short nameFOXP3 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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Alternative nameforkhead box P3 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetforkhead box P3, FOXP3 and IDBG-66215 and ENSG00000049768 and 50943, NFAT protein binding, nuclei, Foxp3 and IDBG-128986 and ENSMUSG00000039521 and 20371, FOXP3 and IDBG-637186 and ENSBTAG00000013279 and 506053
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Gene info
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Identity
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Gene
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Long gene nameforkhead box P3
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Synonyms gene
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Synonyms gene name
- immune dysregulation, polyendocrinopathy, enteropathy, X-linked
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Synonyms
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Locus
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Discovery year2000-05-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Forkhead boxes
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data