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anti-CBFb polyclonal antibody

  • Catalog number
  • Product name
    anti-CBFb polyclonal antibody
  • Size
    CBFb polyclonal antibody
  • Price
  • Supplier
    biovision antibodies-kits-proteins
  • Ask
  • Antibody host:
  • This antibody reacts with:
  • Purification method:
    Whole Anti-Sera
  • Immunogene sequence:
    Polyclonal antibody raised in rabbit against human CBFb (core-binding factor, beta subunit) using two KLH conjugated synthetic peptides containing sequences from the central region of the protein.
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Form of antibody:
  • This antibody has been succesfully tested for use in following methods:
    ELISA, ChIP.
  • Target of this antibody:
  • Formulation of this antibody:
    In PBS with 0.05% (W/V) sodium azide.
  • Alternative names of antibody target:
    PEBP2B, CBF-beta, PEA2-beta, PEB2-beta
  • Recommended usage:
    ChIP: 4 µl/ChIP, ELISA: 1:500.
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • Clonality of antibody:
  • Isotype:
    Rabbit IgG
  • Clone:
  • Background information:
    CBFb represents the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. These transcription factors regulate a host of genes specific to hematopoiesis (e.g. RUNX1) and osteogenesis (e.g. RUNX2). The beta subunit is the regulatory subunit which allosterically enhances the activity of the DNA binding alpha subunit as the complex binds to the core site of various enhancers and promoters. CBFb can be involved in a chromosomal rearrangement of chromosome 16 (inv(16)(p13q22)) which produces a fusion protein consisting of the N terminus of CBFb and the C-terminal portion of MYH11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype.
  • Concentration of antibody:
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • French translation
  • Gene target
  • Short name
    anti-CBFb polyclonal antibody
  • Technique
    anti, antibody to
  • Alternative name
    antibody to-CBFb polyclonal (Antibody to)
  • Alternative technique
  • Ask
1. Gene info
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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