anti-Caspase-10 Antibody
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Catalog number1128
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PricePlease ask
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Size0.02 mg, 0.1 mg
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Gene infoCaspase-10 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch4 and renamed as caspase-10. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP. Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death. Caspase-10 is expressed in many tissues and cell lines.
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Gene namesCaspase-10 Antibody: MCH4, Caspase-10, Apoptotic protease Mch-4, CASP-10
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Antibodie s labelunlabelled serum
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PurityCaspase-10 Antibody is Antibody is DEAE purified.
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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Spicific toAntibody only recognizes FLICE2 form of caspase-10.
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AntigenCaspase-10 antibody was made against a 17 amino acid peptide near the carboxy terminus of human Caspase-10.
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Immuno applicationELISA, Western Blot
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Antibody adviceCaspase-10 antibody can be used for detection of caspase-10 by Western blot 1 ug/mL. A 59 kDa band can be detected.
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Suspention pH azideCaspase-10 Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep atCaspase-10 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works withHuman
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Omim nr4731237
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Ncbi nrAAD28402
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Vial with antibodyin solution
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NCBI GENE nr843
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GENE symbolCASP10
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Antigene namecaspase 10, apoptosis-related cysteine peptidase
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SourceHomo sapiens
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Protein nrQ92851
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use. Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolCARD10, CASP10, RFFL
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Short nameanti-Caspase-10 Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toCasp-10 (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namecaspase recruitment domain family member 10
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Synonyms gene name
- caspase recruitment domain family, member 10
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-09-19
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Membrane associated guanylate kinases
- Caspase recruitment domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecaspase 10
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Synonyms gene name
- caspase 10, apoptosis-related cysteine protease
- caspase 10, apoptosis-related cysteine peptidase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-04-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Caspases
- Death effector domain containing
- Death inducing signaling complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namering finger and FYVE like domain containing E3 ubiquitin protein ligase
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Synonyms gene name
- ring finger and FYVE-like domain containing
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2005-08-16
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Ring finger proteins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data