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anti-Caspase-1 Antibody

  • Catalog number
    3019-100
  • Product name
    anti-Caspase-1 Antibody
  • Size
    Caspase-1 Antibody
  • Price
    371EUR
  • Supplier
    Biovision
  • Ask
  • Target of this antibody:
    Caspase-1
  • Alternative names of antibody target:
    CASP1, IL1BCE, P45, Interleukin-1 beta convertase, IL-1BC, IL1BC, p45, IL1B-convertase, CASP-1, ICE
  • Background information:
    Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-1 (ICE, interleukin-1β-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1β and IL-18 into active cytokines. Like other caspases, Caspase-1 itself is synthesized as a pro-enzyme that is cleaved during activation into a large (20 kDa) and small (10 kDa) subunits. The cellular role of caspase-1 appears limited to cytokine activation as they do not have obvious roles in apoptosis.
  • Antibody host:
    Rabbit
  • Clonality of antibody:
    Polyclonal
  • Isotype:
    Rabbit IgG
  • This antibody reacts with:
    Human, mouse, rat
  • Immunogene sequence:
    Synthetic peptide surrounding amino acid 132 of human caspase-1
  • Concentration of antibody:
    0.2 mg/ml
  • Form of antibody:
    Liquid
  • Formulation of this antibody:
    100 µg (0.2 mg/ml) affinity purified rabbit anti-caspase-1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
  • Purification method:
    Affinity purified
  • This antibody has been succesfully tested for use in following methods:
    Western blot, Immunoprecipitation, Immunofluorescence
  • Recommended usage:
    Western blot analysis (0.5-4 µg/ml), immunoprecipitation (4-8 µg/ml) and immunofluorescence (10-20 µg/ml). The immunoaffinity purified antibody recognizes 45 kDa procaspase-1 and the 20 kDa cleaved product.
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
  • Properties
    If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
  • Short name
    anti-Caspase-1 Antibody
  • Technique
    Antibody, antibody to, antibodies against human proteins, antibodies for
  • Alternative name
    antibody to-caspase-1 (Antibody to)
  • Alternative technique
    antibodies
  • Ask
1. Gene info
  • Identity
  • Gene
  • Long gene name
    caspase 1
  • Synonyms gene
  • Synonyms gene name
    • caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
    • caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
    • caspase 1, apoptosis-related cysteine peptidase
  • Synonyms
  • Synonyms name
  • GenBank acession
  • Locus
  • Discovery year
    1992-05-07
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Caspase recruitment domain containing
    • Caspases
  • Havana BLAST/BLAT
MESH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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