anti-CAD Antibody

  • Catalog number
    2007
  • Price
    Please ask
  • Size
    0.02 mg, 0.1 mg
  • Gene info
    CAD Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40. Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.
  • Gene names
    CAD Antibody: CAD, CPAN, 40kDa, DFF40, Didff, 5730477D02Rik, Cad, DNA fragmentation factor subunit beta, Caspase-activated deoxyribonuclease, CAD
  • Antibodie s label
    unlabelled serum
  • Purity
    CAD Antibody is affinity chromatography purified via peptide column.
  • Ab raised in
    Rabbit
  • Type
    Polyclonal
  • Immunoglobulin
    IgG
  • Antigen
    CAD antibody was made against a peptide corresponding to 17 amino acids near the center of murine CAD.
  • Immuno application
    ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
  • Antibody advice
    CAD antibody can be used for detection of CAD by Western blot at 2 ug/mL. A 40 kDa band should be detected. Antibody can also be used for immunohistochemistry starting at 2 ug/mL. For immunofluorescence start at 10 ug/mL.
  • Suspention pH azide
    CAD Antibody is supplied in PBS containing 0.02% sodium azide.
  • Keep at
    CAD antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Works with
    Mouse, Rat
  • Omim nr
    20137695
  • Ncbi nr
    O54788
  • KDa
    40 kDa
  • Vial with antibody
    in solution
  • NCBI GENE nr
    13368
  • GENE symbol
    Dffb
  • Antigene name
    DNA fragmentation factor, beta subunit
  • Source
    Homo sapiens
  • Protein nr
    O54788
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
  • Properties
    If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • French translation
    anticorps
  • Gene target
    CAD  
  • Gene symbol
    CALD1, CAD, B4GALNT2, ACOD1, CDH12P2, DFFB
  • Short name
    anti-CAD Antibody
  • Technique
    Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
  • Alternative name
    Antibody toCAD (antibody to-)
  • Alternative technique
    antibodies
Gene info
Gene info
  • Identity
  • Gene
    CAD
  • Long gene name
    carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2001-06-22
  • Entrez gene record
    790
  • Pubmed identfication
  • Classification
    • Glutamine amidotransferase class 1 domain containing
  • VEGA ID
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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