anti-CAD Antibody
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Catalog number2007
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PricePlease ask
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Size0.02 mg, 0.1 mg
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Gene infoCAD Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40. Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.
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Gene namesCAD Antibody: CAD, CPAN, 40kDa, DFF40, Didff, 5730477D02Rik, Cad, DNA fragmentation factor subunit beta, Caspase-activated deoxyribonuclease, CAD
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Antibodie s labelunlabelled serum
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PurityCAD Antibody is affinity chromatography purified via peptide column.
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Ab raised inRabbit
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TypePolyclonal
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ImmunoglobulinIgG
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AntigenCAD antibody was made against a peptide corresponding to 17 amino acids near the center of murine CAD.
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Immuno applicationELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
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Antibody adviceCAD antibody can be used for detection of CAD by Western blot at 2 ug/mL. A 40 kDa band should be detected. Antibody can also be used for immunohistochemistry starting at 2 ug/mL. For immunofluorescence start at 10 ug/mL.
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Suspention pH azideCAD Antibody is supplied in PBS containing 0.02% sodium azide.
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Keep atCAD antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Works withMouse, Rat
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Omim nr20137695
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Ncbi nrO54788
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KDa40 kDa
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Vial with antibodyin solution
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NCBI GENE nr13368
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GENE symbolDffb
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Antigene nameDNA fragmentation factor, beta subunit
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SourceHomo sapiens
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Protein nrO54788
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
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PropertiesIf you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolCALD1, CAD, B4GALNT2, ACOD1, CDH12P2, DFFB
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Short nameanti-CAD Antibody
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TechniqueAntibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
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Alternative nameAntibody toCAD (antibody to-)
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Alternative techniqueantibodies
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Gene info
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Identity
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Gene
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Long gene namecaldesmon 1
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Synonyms
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GenBank acession
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Locus
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Discovery year1992-07-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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Classification
- Glutamine amidotransferase class 1 domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namebeta-1,4-N-acetyl-galactosaminyltransferase 2
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Synonyms gene
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Synonyms gene name
- UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase
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Synonyms
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GenBank acession
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Locus
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Discovery year2004-02-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Beta 4-glycosyltransferases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameaconitate decarboxylase 1
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Synonyms gene
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Synonyms gene name
- immunoresponsive 1 homolog (mouse)
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Synonyms
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Locus
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Discovery year2007-11-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecadherin 12 pseudogene 2
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Synonyms gene
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Synonyms gene name
- cadherin 12 (N-cadherin 2) pseudogene
- cadherin 12 (N-cadherin 2) pseudogene 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1995-11-30
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Entrez gene record
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Pubmed identfication
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameDNA fragmentation factor subunit beta
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Synonyms gene name
- DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
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Synonyms
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Synonyms name
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Locus
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Discovery year1997-10-27
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data