anti-BCMA (TNFRSF17) Antibody
This antibody reacts with:
Affinity purified rabbit IgG
Synthetic peptide of human BCMA at C-terminal
How to handle this antibody:
The antibody solution should be gently mixed before use.
Form of antibody:
This antibody has been succesfully tested for use in following methods:
Target of this antibody:
Formulation of this antibody:
100 µg (0.5 mg/ml) of antibody in PBS pH 7.2, 0.01 % BSA, 0.03 % ProClin®, and 50 % glycerol.
Alternative names of antibody target:
B Cell Maturation, BCM, CD269, TNFRSF17, 109545, Q02223, BCMA
Western blot: 1-4 µg
Shelf time: 12 months in temp.: -20 deg.C
Clonality of antibody:
BCMA, also named TNFRSF17, is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf-κ-b and jnk. TNFRSF17 is a member of the TNF-receptor superfamily. TNFRSF17 is expressed in mature B lymphocytes, and is involved in B cell development and autoimmune response. TNFRSF17 specifically binds to the tumor TNFSF13B/TALL-1/BAFF, which causes NF-κB and MAPK8/JNK activation. TNFRSF17 binds to a variety of TRAF family members, and therefore transduces signals for cell survival and proliferation. TNFRSF17 is a type III membrane protein having 1 extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs. TNFRSF17 appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells.
Concentration of antibody:
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
If you buy Antibodies supplied by biovision antibodies-kits-proteins they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
anti-BCMA (TNFRSF17) Antibody
Antibody, antibody to, antibodies against human proteins, antibodies for
antibody to-BCMA (tumor necrosis factor receptor superfamily, member 17) (Antibody to)
Alternative to gene target
tumor necrosis factor receptor superfamily, member 17, BCM and BCMA and CD269 and TNFRSF13A, TNFRSF17 and IDBG-15042 and ENSG00000048462 and 608, this GO :0002376 and immune system process and biological process this GO :0004872 and receptor activity and molecular function this GO :0005031 and tumor necrosis factor-activated receptor activity and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0007165 and signal transduction and biological process this GO :0007275 and multicellular organismal development and biological process this GO :0008283 and cell proliferation and biological process this GO :0012505 and endomembrane system and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0033209 and tumor necrosis factor-mediated signaling pathway and biological process, tumor necrosis factor-activated receptor activity, this GO :0004872: receptor activity and also this GO :0005031: tumor necrosis factor-activated receptor activity, this GO :0004872: receptor activity, this GO :0005031: tumor necrosis factor-activated receptor activity, Plasma membranes, Tnfrsf17 and IDBG-133357 and ENSMUSG00000022496 and 21935
1. Gene info
Scope note:Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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