anti-ASK1 Antibody

• Catalog number
  1151
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  ASK1 Antibody: Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including cytokines, growth factors and environmental stresses. A novel MAP kinase kinase kinase (MAPKKK) was recently identified and designated ASK1 (for apoptosis signal-regulating kinase 1) and MAPKKK5. ASK1 activated two different subgroups of MAPKK, MKK4 and MKK6, which in turn activated c-Jun N-terminal kinase (JNK) and p38 MAP kinase, respectively. ASK1/MAPKKK5 is activated by TNFR and Fas through the interaction with members of the TRAF family and Fas-associated protein Daxx. Overexpression of ASK1 induced apoptotic cell death, and a catalytically inactive form of ASK1 inhibited TNF-a;-induced apoptosis. ASK1 is expressed in variety of human and mouse tissues.
• Gene names
  ASK1 Antibody: ASK1, MEKK5, MAPKKK5, ASK1, Mitogen-activated protein kinase kinase kinase 5, Apoptosis signal-regulating kinase 1, ASK-1
• Antibodie s label
  unlabelled serum
• Purity
  ASK1 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  ASK1 antibody was made against a peptide corresponding to amino acids near the carboxy terminus of human ASK1. This sequence is different from that of mouse by last two amino acids.
• Immuno application
  ELISA, Western Blot, immuno-cyto-chemistry, immuno fluorescence
• Antibody advice
  ASK1 antibody can be used for detection of ASK1 by Western blot at 0.5 ug/mL. A 155 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 ug/mL. For immunofluorescence start at 20 ug/mL.
• Suspention pH azide
  ASK1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  ASK1 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human
• Omim nr
  6685617
• Ncbi nr
  Q99683
• KDa
  155 kDa
• Vial with antibody
  in solution
• NCBI GENE nr
  4217
• GENE symbol
  MAP3K5
• Antigene name
  mitogen-activated protein kinase kinase kinase 5
• Source
  Homo sapiens
• Protein nr
  Q99683
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ASK1  
• Gene symbol
  MAP3K5
• Short name
  anti-ASK1 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toASK1 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6857
• Gene
  MAP3K5
• Long gene name
  mitogen-activated protein kinase kinase kinase 5
• Synonyms gene
  • MEKK5
• Synonyms
  • MAPKKK5
  • ASK1
• Synonyms name
  • apoptosis signal regulating kinase 1
• GenBank acession
  • U67156
• Locus
  6q23.3
• Discovery year
  1997-11-14
• Entrez gene record
  4217
• Pubmed identfication
  • 9465908
• Classification
  • Mitogen-activated protein kinase kinase kinases
• VEGA ID
  OTTHUMG00000015647
• Locus Specific Databases
  • The Globin Gene Server

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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