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anti-Anti-Osteopontin (CT) (Clone 1F11)

  • Catalog number
    5426-100
  • Product name
    anti-Anti-Osteopontin (CT) (Clone 1F11)
  • Size
    Anti-Osteopontin (CT) (Clone 1F11)
  • Price
    338EUR
  • Supplier
    biovision antibodies-kits-proteins
  • Ask
  • Antibody host:
    Mouse
  • This antibody reacts with:
    Recognizes native human Osteopontin from purified breast milk. Specific for the C-terminal fragment of full-length Osteopontin.
  • Purification method:
    Protein A chromatography from ascites
  • Immunogene sequence:
    Recombinant full-length human Osteopontin
  • How to handle this antibody:
    The antibody solution should be gently mixed before use.
  • Form of antibody:
    Liquid
  • This antibody has been succesfully tested for use in following methods:
    ELISA, Western Blot.
  • Target of this antibody:
    Osteopontin
  • Formulation of this antibody:
    1 mg/ml in 0.15 M PBS
  • Alternative names of antibody target:
    OPN, BNSP, Bone sialoprotein 1, Nephropontin, Secreted phosphoprotein 1, SPP-1, Urinary stone protein, Uropontin.
  • Recommended usage:
    N/A
  • Storage information:
    Shelf time: 12 months in temp.: -20 deg.C
  • Shipping conditions:
    gel pack
  • Clonality of antibody:
    Monoclonal
  • Isotype:
    Mouse IgG1κ
  • Clone:
    1F11
  • Background information:
    Human Osteopontin (OPN) is a negatively charged hydrophilic protein of 314 amino acids and is subject to significant post translational modifications (PTM) including phosphorylation and glycosylation. Due to its acidic nature and PTMs, OPN runs anomalously by SDS-PAGE. Althoμgh its mass is 35kD, apparent molecular weights may range up to 75kD. In addition, OPN is subject to proteolytic modification into smaller molecular weight fragments. The matricellular protein osteopontin binds to cell surface receptors and is secreted into many body fluids including milk, blood and urine, depending on the organ of origin. This makes osteopontin an ideal candidate for being a biomarker as the secreted form is easily obtained in throwaway fluids, and mimics the cellular environment from which it is released. Osteopontin is important in immune responses and inflammation as well as bone generation and remodeling. In autistic children, serum levels of osteopontin are correlated to the severity of disease, probably due to a brain inflammation pattern in these children. In aortic valve sclerosis and stenosis, increased levels of secreted osteopontin are also noted. Osteopontin has also been sμggested as a cancer biomarker, since it is associated with tumor formation, progression and metastasis. In bone and tooth formation osteopontin is known to be a negative regulator of parathyroid hormone-related protein receptor, which induces osteogenesis. Without appropriate levels of osteopontin, bone growth continues unregulated, and leads to specific bone cancers. In short, osteopontin is a strong marker for bone growth, inflammation and certain cancers.
  • Concentration of antibody:
    1 mg/ml
  • Description
    This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
  • Gene target
  • Short name
    anti-Anti-Osteopontin (CT) (Clone 1F11)
  • Technique
    anti, antibody to
  • Alternative name
    antibody to-Anti-Osteopontin (CT) (clonality 1F11)
  • Alternative technique
    antibodies
  • Clone name
    1F11
  • Ask
1. Gene info
MESH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    classification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics
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