TNF beta protein

Category

Proteins
Antibody Subtype

Recombinant Proteins
Area of research

Cytokines & Growth Factors
Reactivity

Human
Type of protein

Recombinant
Expression System

Escherichia coli
Grade Purity

Grater than 98% pure
Method of Purification

TNF beta protein was purified using a a proprietary chromatographic technique.
Form Buffer

Provided in lyophilized form with no additives
Storage

Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Shipping conditions

Blue Ice
Bioactivity

The ED50 as determined by the cytolysis of murine L929 cells in the presence of actinomycin D is < 0.005 ng/ml, corresponding to a specific activity of > 2 x 10^7 units/mg
URL
More info
Gene

Tumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.

Gene target

TNF beta protein
Gene symbol

TNF, TNFRSF1A, TNFRSF1B, LTBR
Short name

TNF beta protein
Alternative name

Purified recombinant Human TNF beta protein
Alternative to gene target

tumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943

Identity

HGNC:11916
Gene

TNFRSF1A
Long gene name

TNF receptor superfamily member 1A
Synonyms gene
- TNFR1
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 1A
Synonyms
- TNF-R
- TNFAR
- TNFR60
- TNF-R-I
- CD120a
- TNF-R55
GenBank acession
- M75866
Locus

12p13.31
Discovery year

1991-01-15
Entrez gene record

7132
Pubmed identfication
- 1655358
- 2158863
RefSeq identity
- NM_001065
Classification
- Tumor necrosis factor receptor superfamily
- CD molecules
VEGA ID

OTTHUMG00000168267
Locus Specific Databases
- INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
- LRG_193

Identity

HGNC:11917
Gene

TNFRSF1B
Long gene name

TNF receptor superfamily member 1B
Synonyms gene
- TNFR2
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 1B
Synonyms
- TNFBR
- TNFR80
- TNF-R75
- TNF-R-II
- p75
- CD120b
GenBank acession
- M32315
Locus

1p36.22
Discovery year

1991-01-15
Entrez gene record

7133
Pubmed identfication
- 2158863
- 8702885
RefSeq identity
- NM_001066
Classification
- CD molecules
- MicroRNA protein coding host genes
- Tumor necrosis factor receptor superfamily
VEGA ID

OTTHUMG00000001829