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Category
Secondary Antibody
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Antibody Subtype
Unconjugated Secondary Antibodies
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Area of research
Immunology
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Type of Immunogen
Mouse IgE antibodies were raised in rat using murine IgE ..
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Raised in
Rat
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Specificity
Murine
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Cross Reactivity
Should be determined by the end user
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Isotypes
IgG1 kappa
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Clone
LO-ME-3
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Concentration
1.0 mg/ml
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Form Buffer
PBS with 0.1% NaN3.
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Storage
Aliquot and store at -20 deg C. Avoid repeated Freeze/Thaw cycles
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Shipping conditions
Blue Ice
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Tested for
ELISA
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Usage Recommendations
Optimal conditions to be determined by end user
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. This is against a protein of mus musculus directed antibody.
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Properties
Immunoglobulin E (IgE) kappa or Fc specific antibody is a kind of antibody (or immunoglobulin (Ig) "isotype") that has only been found in mammals. IgE is synthesized by plasma cells. Monomers of IgE consist of two heavy chains (ε chain) and two light chains, with the ε chain containing 4 Ig-like constant domains (Cε1-Cε4). IgEs play a role in allergy and response to parasite infection. High levels of IgEs caused by parasites can lower the allergic reaction of patients to allergens common present in the human environment. As such the parasite history of an allergic patient needs to be taken in consideration as a positive factor.
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Test
Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
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Latin name
Mus musculus, Rattus norvegicus
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About
Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
