anti- ALDH2 antibody

• Catalog number
  FNab00291
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
• Immunogen
  aldehyde dehydrogenase 2 family (mitochondrial)
• Synonyms
  ALDH class 2, ALDH E2, ALDH2, ALDHI, ALDM
• Calculated MW
  53 kDa
• Uniprot ID
  P05091
• Specificity
  Human, Mouse, Rat
• Tested Application
  ELISA, WB, IHC, IF
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
• Image1
  Immunohistochemistry of paraffin-embedded human liver using FNab00291(ALDH2 antibody) at dilution of 1:100
• Image4
  mouse lung tissue were subjected to SDS PAGE followed by western blot with FNab00291(ALDH2 antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ALDH2  
• Gene symbol
  ALDH2
• Short name
  anti- ALDH2 antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- aldehyde dehydrogenase 2 family (mitochondrial) (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  aldehyde dehydrogenase 2 family (mitochondrial), ALDH-E2 and ALDHI and ALDM, ALDH2 and IDBG-57710 and ENSG00000111275 and 217, oxidoreductase activity, multiple

Gene info

• Identity
  HGNC:404
• Gene
  ALDH2
• Long gene name
  aldehyde dehydrogenase 2 family member
• Synonyms gene name
  • aldehyde dehydrogenase 2 family (mitochondrial)
• GenBank acession
  • M26760
• Locus
  12q24.12
• Discovery year
  1986-01-01
• Entrez gene record
  217
• Pubmed identfication
  • 4015823
  • 2987944
• RefSeq identity
  • NM_000690
• Classification
  • Aldehyde dehydrogenases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000169603
• Locus Specific Databases
  • Human Polymorphisms of ALDH Genes

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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