Human TRAIL-R2 (DR5/ TNFRSF10B)/Fc Chimera
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Catalog number
RL-EXB0007-C050
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Price
Please ask
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Size
50ug
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Type
Recombinant protein
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Expression system
HEK 293 cell line
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Description
DR5 is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L). Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF related apoptosis inducing ligand) and Apo2L (for Apo2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. The extracellular domain of human TRAIL-R2 (aa 1 - 182) is fused to the Fc portion of human IgG1.
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Format
Lyophilized powder
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Purity
> 95% determined by SDS-PAGE
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Purification methd
Purified from cell culture supernatant via protein-A affinity chromatography
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Shipping and storage
Store lyophilized product in freezer (-20 °C to -80 °C). The expiration date of unopened product vial is indicated on the vial label. After reconstitution prepare suitable aliquots. Reconstituted product is stable for at least 6 months when stored in freezer (-20 °C to -80 °C). Avoid freeze/thaw cycles.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Gene target
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Gene symbol
TNFRSF10B, PCAT7, TNFSF10, CD82, CLDN3
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Short name
TRAIL-R2 (DR5/ TNFRSF10B)/Fc
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Technique
FC, Fc chimeras and Chimera RNAi's are part non target species constructions.
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Species
Human, Humans
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Alternative name
Recombinant human TRAIL-R2 (DR5/ TNFRSF10B)/Fc Chimera
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Alternative to gene target
tumor necrosis factor receptor superfamily, member 10b, CD262 and DR5 and KILLER and KILLER/DR5 and TRAIL-R2 and TRAILR2 and TRICK2 and TRICK2A and TRICK2B and TRICKB and ZTNFR9, TNFRSF10B and IDBG-11376 and ENSG00000120889 and 8795, TRAIL binding, Plasma membranes
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Gene info
Gene info
Gene info
Gene info
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Identity
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Gene
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Long gene name
CD82 molecule
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Synonyms gene
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Synonyms gene name
- kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4))
- CD82 antigen
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1994-01-10
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Entrez gene record
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RefSeq identity
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Classification
- Tetraspanins
- CD molecules
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
claudin 3
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1998-07-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Product images
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