Human TRAIL-R1 (DR4/ TNFRSF10A)/Fc Chimera

• Catalog number
  RL-EXB0006-C050
• Price
  Please ask
• Size
  50ug

• Type
  Recombinant protein
• Expression system
  HEK 293 cell line
• Description
  DR4 is a transmembrane protein, also called TRAIL receptor 1 (TRAIL-R1). The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor). The extracellular domain of human TRAIL-R1 (aa 1 - 238) is fused to the Fc portion of human IgG1.
• Format
  Lyophilized powder
• Purity
  > 95% determined by SDS-PAGE
• Purification methd
  Purified from cell culture supernatant via protein-A affinity chromatography
• Shipping and storage
  Store lyophilized product in freezer (-20 °C to -80 °C). The expiration date of unopened product vial is indicated on the vial label. After reconstitution prepare suitable aliquots. Reconstituted product is stable for at least 6 months when stored in freezer (-20 °C to -80 °C). Avoid freeze/thaw cycles.
• Datasheet
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

• Gene target
  TRAIL-R1   DR4   TNFRSF10A  
• Gene symbol
  TNFRSF10A, TNFRSF10A-DT, C17orf75, CDCA7L, TNFRSF10A-AS1, CNEP1R1, TNFSF10, TNFRSF10B, CXCL11, PNPLA7
• Short name
  TRAIL-R1 (DR4/ TNFRSF10A)/Fc
• Technique
  FC, Fc chimeras and Chimera RNAi's are part non target species constructions.
• Species
  Human, Humans
• Alternative name
  Recombinant human TRAIL-R1 (DR4/ TNFRSF10A)/Fc Chimera
• Alternative to gene target
  tumor necrosis factor receptor superfamily, member 10a, APO2 and CD261 and DR4 and TRAILR-1 and TRAILR1, TNFRSF10A and IDBG-11715 and ENSG00000104689 and 8797, TRAIL binding, Plasma membranes

Gene info

• Identity
  HGNC:11904
• Gene
  TNFRSF10A
• Long gene name
  TNF receptor superfamily member 10a
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 10a
• Synonyms
  • DR4
  • Apo2
  • TRAILR-1
  • CD261
  • TRAILR1
• GenBank acession
  • U90875
• Locus
  8p21.3
• Discovery year
  1998-12-04
• Entrez gene record
  8797
• Pubmed identfication
  • 9311998
  • 9082980
• RefSeq identity
  • NM_003844
• Classification
  • CD molecules
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000097843

Gene info

• Identity
  HGNC:52647
• Gene
  TNFRSF10A-DT
• Long gene name
  TNFRSF10A divergent transcript
• Synonyms
  • LOC389641
• Locus
  8p21.3
• Discovery year
  2021-04-29
• Entrez gene record
  389641
• Pubmed identfication
  • 26708505
• RefSeq identity
  • NR_033928
• Classification
  • Divergent transcripts

Gene info

• Identity
  HGNC:30173
• Gene
  C17orf75
• Long gene name
  chromosome 17 open reading frame 75
• Synonyms
  • NJMU-R1
  • SRI2
• Synonyms name
  • sensitization to ricin complex subunit 2
• GenBank acession
  • AB062437
• Locus
  17q11.2
• Discovery year
  2006-01-12
• Entrez gene record
  64149
• Pubmed identfication
  • 23394947
  • 29426865
• RefSeq identity
  • NM_022344
• VEGA ID
  OTTHUMG00000179585

Gene info

• Identity
  HGNC:30777
• Gene
  CDCA7L
• Long gene name
  cell division cycle associated 7 like
• Synonyms gene name
  • cell division cycle associated 7-like
• Synonyms
  • RAM2
  • R1
  • JPO2
• Locus
  7p15.3
• Discovery year
  2005-05-13
• Entrez gene record
  55536
• Pubmed identfication
  • 16829576
• RefSeq identity
  • NM_018719
• VEGA ID
  OTTHUMG00000128429

Gene info

• Identity
  HGNC:53164
• Gene
  TNFRSF10A-AS1
• Long gene name
  TNFRSF10A antisense RNA 1
• Synonyms
  • RP11-1149O23.2
• Locus
  8p21.3
• Discovery year
  2017-03-03
• Pubmed identfication
  • 27727196
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:26759
• Gene
  CNEP1R1
• Long gene name
  CTD nuclear envelope phosphatase 1 regulatory subunit 1
• Synonyms gene
  • C16orf69
  • TMEM188
• Synonyms gene name
  • chromosome 16 open reading frame 69
  • transmembrane protein 188
• Synonyms
  • FLJ38101
  • NEP1-R1
• Synonyms name
  • nuclear envelope phosphatase 1-regulatory subunit 1
• GenBank acession
  • AK095420
• Locus
  16q12.1
• Discovery year
  2006-04-07
• Entrez gene record
  255919
• Pubmed identfication
  • 22134922
• RefSeq identity
  • NM_153261
• VEGA ID
  OTTHUMG00000173447

Gene info

• Identity
  HGNC:11925
• Gene
  TNFSF10
• Long gene name
  TNF superfamily member 10
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 10
• Synonyms
  • TRAIL
  • Apo-2L
  • TL2
  • CD253
• GenBank acession
  • U37518
• Locus
  3q26
• Discovery year
  1998-12-04
• Pubmed identfication
  • 8777713
  • 8663110
• Classification
  • CD molecules
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000156917

Gene info

• Identity
  HGNC:11905
• Gene
  TNFRSF10B
• Long gene name
  TNF receptor superfamily member 10b
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 10b
• Synonyms
  • DR5
  • KILLER
  • TRICK2A
  • TRAIL-R2
  • TRICKB
  • CD262
  • TRAILR2
• GenBank acession
  • AF012628
• Locus
  8p21.3
• Discovery year
  1998-12-04
• Entrez gene record
  8795
• Pubmed identfication
  • 9285725
  • 9311998
• RefSeq identity
  • NM_147187
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000097826

Gene info

• Identity
  HGNC:10638
• Gene
  CXCL11
• Long gene name
  C-X-C motif chemokine ligand 11
• Synonyms gene
  • SCYB9B
  • SCYB11
• Synonyms gene name
  • small inducible cytokine subfamily B (Cys-X-Cys), member 11
  • chemokine (C-X-C motif) ligand 11
• Synonyms
  • H174
  • b-R1
  • I-TAC
  • IP-9
• GenBank acession
  • U66096
• Locus
  4q21.1
• Discovery year
  1998-06-23
• Entrez gene record
  6373
• Pubmed identfication
  • 9730616
• Classification
  • Chemokine ligands
• VEGA ID
  OTTHUMG00000130101

Gene info

• Identity
  HGNC:24768
• Gene
  PNPLA7
• Long gene name
  patatin like phospholipase domain containing 7
• Synonyms gene
  • C9orf111
• Synonyms gene name
  • chromosome 9 open reading frame 111
  • patatin-like phospholipase domain containing 7
• Synonyms
  • FLJ43070
  • FLJ31318
  • FLJ44279
  • RP11-48C7.2
  • NTEL1
  • NTE-R1
• GenBank acession
  • AK126267
• Locus
  9q34.3
• Discovery year
  2004-03-25
• Entrez gene record
  375775
• Pubmed identfication
  • 16799181
  • 12640454
  • 19029121
• RefSeq identity
  • NM_152286
• Classification
  • Patatin like phospholipase domain containing
• VEGA ID
  OTTHUMG00000020990

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