Akt1 / PKB PAb

• Catalog number
  11-509-C050
• Price
  Please ask
• Size
  0.05 mg

• Long name
  Rabbit Polyclonal Antibody against Human Akt1 / PKB, Clone: PAb
• Antigen
  Akt1 / PKB
• Species reactivity
  Human (Homo sapiens)
• Negative species reactivity
  at the time of upload there has been no data, please, contact us to obtain most recent information on species reactivity and cross reactivity
• Clonality
  Polyclonal Antibody (PAb)
• Clone
  Polyclonal
• Applications
  WB
• Immunogen
  Synthetic peptide (coupled with KLH) derived from aminoacid sequence 85-100 of human Akt1. This immunogen sequence has 100% homology with mouse and rat Akt1/PKB.
• Format conjugation
  purified; unconjugated
• Specificity
  The polyclonal antibody reacts with Akt1 (recognized epitope: between aa 85-100 of Akt1/PKB). Akt/PKB protein kinases family has a three mammalian members identified to date (Akt1, Akt2, Akt3). Human Akt1 has a predicted molecular weight of 55.7 kDa._x000D_ _x000D_
• Research area
  Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Human), Phosphorylation (Kinases, Phosphatases, Phosphotyrosine)
• Concentration
  1 mg/ml
• Storage buffer
  The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
• Shipping and storage
  Rabbit Polyclonal Antibody against Human Akt1 / PKB, Clone: PAb is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  Serine/threonine protein kinase Akt/PKB (Protein Kinase B) plays important roles in cell growth, metabolism, proliferation and survival. Upon extracellular stimulus that leads to activation of phosphatidylinositol 3-kinase (PI3K), Akt is recruited from the cytosol to the plasma membrane through binding 3´phosphoinositides and is phosphorylated. Active Akt dissociates from the plasma membrane to gain access to various substrates in different subcellular locations by translocating to cytosol and nucleus. _x000D_
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified from rabbit serum by affinity chromatography
• Datasheet
• References
  Contact us for the most recent list of references

• Gene target
  Akt1   PKB   PAb  
• Gene symbol
  AKT1
• Short name
  Anti-Akt1 / PKB PAb
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  IgG (various subtypes)
• Alternative name
  Rabbit Polyclonal to Akt1 / PKB
• Alternative to gene target
  v-akt murine thymoma viral oncogene homolog 1, AKT and CWS6 and PKB and PKB-ALPHA and PRKBA and RAC and RAC-ALPHA, AKT1 and IDBG-22709 and ENSG00000142208 and 207, phosphatidylinositol-3, nuclei, Akt1 and IDBG-174623 and ENSMUSG00000001729 and 11651, AKT1 and IDBG-635767 and ENSBTAG00000017636 and

Gene info

• Identity
  HGNC:391
• Gene
  AKT1
• Long gene name
  AKT serine/threonine kinase 1
• Synonyms gene name
  • v-akt murine thymoma viral oncogene homolog 1
• Synonyms
  • RAC
  • PKB
  • PRKBA
  • AKT
  • RAC-alpha
• Synonyms name
  • protein kinase B
• GenBank acession
  • M63167
• Locus
  14q32.33
• Discovery year
  1986-01-01
• Entrez gene record
  207
• Pubmed identfication
  • 21214427
• RefSeq identity
  • NM_005163
• Classification
  • Pleckstrin homology domain containing
  • AKT kinases
• VEGA ID
  OTTHUMG00000170795
• Locus Specific Databases
  • LRG_721

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