Recombinant Mouse OX40 Ligand/TNFSF4/OX40L Protein(N-8His)

#

• Catalog number
  PKSM041119-10µg
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• Size
  10µg

# #

• Synonym
  Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD252; Tnfsf4
• Activity
  NA
• Sequence
  Ser51-Leu198
• Fusion tag
  N-8His
• Accession
  P43488
• Expressed Host
  Human Cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  17.7 kDa
• AP Mol Mass
  20-23 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
• Background
  OX40 ligand (OX40L), also called CD252, is a single-pass type II membrane protein of the TNF/TNF receptor superfamily. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. OX40L–OX40 co-stimulation leads to activation of TNF receptor associated factor (TRAF) 2, 3 and 5. This pathway has been shown to prolong the survival of effector CD4+Th cells as well as contributes to generation of memory T cells.
• Technical data
• Description
  FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus
• Source
  Recombinants or rec. proteins
• Group
  recombinants

#

• Gene target
  OX40   Ligand/TNFSF4/OX40L   Protein   N-8His  
• Gene symbol
  TNFRSF4, TNFSF4
• Short name
  Recombinant Mouse OX40 Ligand/TNFSF4/OX40L Protein(N-8His)
• Technique
  Recombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Host
  mouse
• Species
  Mouse, Mouses
• Alternative name
  Rec. Mouse OX40 Ligand/tumor necrosis factor (ligand) superfamily, member 4/OX40L Protein(N-8His)
• Alternative technique
  rec, murine
• Alternative to gene target
  tumor necrosis factor (ligand) superfamily, member 4, CD134L and CD252 and GP34 and OX-40L and OX4OL and TXGP1, TNFSF4 and IDBG-104864 and ENSG00000117586 and 7292, tumor necrosis factor receptor superfamily binding, Extracellular, Tnfsf4 and IDBG-201525 and ENSMUSG00000026700 and 22164, TNFSF4 and IDBG-632319 and ENSBTAG00000002894 and 539800

Gene info

• Identity
  HGNC:11918
• Gene
  TNFRSF4
• Long gene name
  TNF receptor superfamily member 4
• Synonyms gene
  • TXGP1L
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 4
• Synonyms
  • ACT35
  • OX40
  • CD134
• GenBank acession
  • X75962
• Locus
  1p36.33
• Discovery year
  1994-12-15
• Entrez gene record
  7293
• Pubmed identfication
  • 7510240
  • 2828930
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000001415
• Locus Specific Databases
  • LRG_1319

Gene info

• Identity
  HGNC:11934
• Gene
  TNFSF4
• Long gene name
  TNF superfamily member 4
• Synonyms gene
  • TXGP1
• Synonyms gene name
  • tax-transcriptionally activated glycoprotein 1, 34kD
  • tumor necrosis factor (ligand) superfamily, member 4
• Synonyms
  • OX-40L
  • gp34
  • CD252
• GenBank acession
  • D90224
• Locus
  1q25.1
• Discovery year
  1993-12-15
• Entrez gene record
  7292
• Pubmed identfication
  • 1996093
  • 8076595
• Classification
  • Tumor necrosis factor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000034838

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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