Recombinant Human HER4 / ErbB4 Protein (His & Fc tag)

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• Catalog number
  PKSH031649-50µg
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• Size
  50µg

# #

• Synonym
  ALS19;HER4;p180erbB4
• Activity
  1.Measured by its ability to bind biotinylated human Fc-NRG1 (isoform Beta 1) in a functional ELISA.2. Measured by its ability to bind with biotinylated human NRG1 (isoform Beta 1)in a functional ELISA.3. Measured by its ability to bind with biotinylated human NRG1 (aa 2-246)-Fc in a functional ELISA.4. Measured by its ability to bind with biotinylated human NRG1 (aa 20-241)-His in a functional ELISA.
• Sequence
  Met 1-Pro 651
• Fusion tag
  C-His & Fc
• Accession
  NP_001036064.1
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞95 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  97.5 kDa
• AP Mol Mass
  125-135 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Background
  ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is expressed at highest levels in brain, heart, kidney, in addition to skeletal muscle, parathyroid, cerebellum, pituitary, spleen, testis and breast. And lower levels in thymus, lung, salivary gland, and pancreas. It specifically binds to and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. ERBB4 also can be activated by other factors and induces a variety of cellular responses including mitogenesis and differentiation. ERBB4 regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. It is required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. ERBB4 also play a role on the normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal axon guidance. It is required for mammary gland differentiation, induction of milk proteins and lactation.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy
• Technical data
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

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• Gene target
  HER4   ErbB4   Protein   His   tag  
• Gene symbol
  ERBB4
• Short name
  Recombinant HER4 / ErbB4 Protein (His & Fc tag)
• Technique
  Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens HER4 / v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) Protein (histidine & fragment c detection labelled)
• Alternative technique
  rec
• Alternative to gene target
  v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian), ALS19 and HER4 and p180erbB4, ERBB4 and IDBG-79992 and ENSG00000178568 and 2066, transferase activity, nuclei, Erbb4 and IDBG-164078 and ENSMUSG00000062209 and 13869, ERBB4 and IDBG-643612 and ENSBTAG00000012647 and

Gene info

• Identity
  HGNC:3432
• Gene
  ERBB4
• Long gene name
  erb-b2 receptor tyrosine kinase 4
• Synonyms gene name
  • v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
• Synonyms
  • ALS19
  • HER4
• Synonyms name
  • human epidermal growth factor receptor 4
• GenBank acession
  • L07868
• Locus
  2q34
• Discovery year
  1995-09-07
• Entrez gene record
  2066
• Pubmed identfication
  • 7700649
  • 17018285
• RefSeq identity
  • NM_001042599
• Classification
  • Erb-b2 receptor tyrosine kinases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000133012

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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