- Catalog numberCSB-PA07109D0Rb_100ug
- Product nameRabbit Anti Human KIT Antibody-Biotin
- Size100ug
- PriceAsk For Price
- Long nameRabbit Antibody against Human KIT, Biotin
- Short nameAnti-KIT
- Synonym nameKIT Human Antibody
- HostRabbit, Rabbits
- Species reactivityHuman
- Tested applications recommended dilutionsELISA
- ConjugationBiotin
- Antibody isotypeIgG
- UniProt IDP10721
- FormatLiquid, diluted in buffer
- Buffer compositionPreservative: 0.03% Proclin 300, Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
- Purity>95%
- Purification methodProtein G purified
- Antibody categoryPolyclonal Antibodies
- Immunogen typeRecombinant Human Mast/stem cell growth factor receptor Kit protein (73-195AA)
- Immunogen speciesHuman
- AliasMast/stem cell growth factor receptor Kit,SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog,CD117,KIT,SCFR
- BackgroundTyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
- ClonalityPolyclonal antibody
- Shipping and storageKIT Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
- Short name of the antigenMast/stem cell growth factor receptor Kit
- Alternative to gene target
- [ "v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog", "C-Kit and CD117 and PBT and SCFR", "KIT and IDBG-18980 and ENSG00000157404 and 3815", "transferase activity", "Extracellular", "Kit and IDBG-172083 and ENSMUSG00000005672 and 16590", "KIT and IDBG-642326 and ENSBTAG00000002699 and 280832" ]
- Gene targetKIT -
- Identity:HGNC:6342
- Gene:KIT
- Long gene name:KIT proto-oncogene, receptor tyrosine kinase
- Synonyms gene name:piebald trait, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
- Synonyms:CD117, SCFRC-Kit
- Discovery year:1986-01-01
- Entrez gene record:3815
- Pubmed identification:9027509
- RefSeq identity:NM_000222
- Classification:Receptor tyrosine kinases, CD molecules, Immunoglobulin like domain containing
- VEGA ID:OTTHUMG00000128713
- Gene symbolKIT
- LabelBiotin
- label filter
- Biotin
- technique filter
- anti human
- Antibody
- Rabbit
- anti
- Techniqueanti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for
- Alternative techniqueantibodies, rabbit-anti, kits
Gene info
Locus Specific Databases:LRG_307