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Long name
Rabbit Antibody against Human BNIP3L, Non-conjugated
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Synonym name
BNIP3L Human Antibody
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Species reactivity
Human
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Tested applications recommended dilutions
ELISA,IHC;Recommended dilution:IHC:1:20-1:200
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Conjugation
Non-conjugated
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Antibody isotype
IgG
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UniProt ID
O60238
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Format
Liquid, diluted in buffer
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Buffer composition
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Purity
>95%
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Purification method
Antigen Affinity Purified Antibodies
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Antibody category
Polyclonal Antibodies
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Immunogen type
Recombinant human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like protein (1-187AA)
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Immunogen species
Human
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Alias
Adenovirus E1B19K-binding protein B5,BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A,NIP3-like protein X,NIP3L,BNIP3L,BNIP3A, BNIP3H, NIX
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Background
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
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Clonality
Polyclonal antibody
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Shipping and storage
BNIP3L Antibody is shipped on ice packs and upon receipt should be stored at -20 or -80 degrees Celsius. We recommend that you prepare the working aliquots in advance so that freez-thaw cycles are avoided. Do not expose the antibodies to drirect bright light, especially the labeled ones as most conjugates are light sensitive.
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Description
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody against the Hu protein or peptide or recombinant supplied in 1 volumes. Ask for quote if you need bulk.
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Properties
If you buy Antibodies supplied by Cusabio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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About
Rabbits are used for polyclonal antibody production by Cusabio. Rabbit antibodies are very stable and can be stored for several days at room temperature. Cusabio adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
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Latin name
Oryctolagus cuniculus
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French translation
anticorps
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Gene target
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Gene symbol
BNIP3L
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Short name
Anti-BNIP3L
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Technique
anti human, Antibody, Rabbit, anti, antibody to, anti human antibodies, antibodies against human proteins, antibodies for, antibody Conjugates
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Host
Rabbit, Rabbits
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Species
Human, Humans
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Alternative name
BNIP3L Antibody
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Alternative technique
antibodies, rabbit-anti
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Alternative to gene target
BCL2/adenovirus E1B 19kDa interacting protein 3-like, BNIP3a and NIX, BNIP3L and IDBG-13074 and ENSG00000104765 and 665, protein heterodimerization activity, nuclei, Bnip3l and IDBG-175760 and ENSMUSG00000022051 and 100043324,102641641,12177, BNIP3L and IDBG-635626 and ENSBTAG00000021307 and 534615
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