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Target antigen
Chromogranin A
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, mouse, rat
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Analyses
WB,IHC-P
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Immunogen
E.coli-derived human Chromogranin A recombinant protein (Position: K321-G457). Human Chromogranin A shares 80% and 82% amino acid (aa) sequences identity with mouse and rat Chromogranin A, respectively.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the Chromogranin A Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The Chromogranin A Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
CHGA, also known as CGA or chromogranin A, is an acidic protein costored and coreleased with catecholamines from storage granules in the adrenal medulla. CHGA is a member of the granin family of neuroendocrine secretory protein, It is located in secretory vesicles of neurons and endocrine cells. In humans, CHGA protein is encoded by the CHGA gene, and it is mapped to 14q32.12. CHGA gene product is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine).
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Related articles
1. Helman LJ, Ahn TG, Levine MA, Allison A, Cohen PS, Cooper MJ, Cohn DV, Israel MA (August 1988). "Molecular cloning and primary structure of human chromogranin A (secretory protein I) cDNA". J. Biol. Chem. 263 (23): 11559–63. 2. Cotesta D, Caliumi C, Alò P, Petramala L, Reale MG, Masciangelo R, Signore A, Cianci R, D'Erasmo E, Letizia C (2005). "High plasma levels of human chromogranin A and adrenomedullin in patients with pheochromocytoma". Tumori 91 (1): 53–8.
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Gene Name
CHGA
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Protein Name
Chromogranin-A
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Gene Full Name
chromogranin A (parathyroid secretory protein 1)
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Synonyms
beta Granin antibody|CGA antibody|CHG A antibody|CHGA antibody|Chromogranin A parathyroid secretory protein 1 antibody|Chromogranin A precursor antibody|ChromograninA antibody|CMGA_HUMAN antibody|ER-37 antibody|Pancreastatin antibody|Parastatin antibody|Parathyroid secretory protein 1 antibody|Pituitary secretory protein I antibody|SP I antibody|SP-I antibody|SP1 antibody|SPI antibody|Vasostatin antibody|Vasostatin I antibody|Vasostatin II antibody
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Uniprot ID
P10645
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Entrez GeneID
1113
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
