Zosuquidar trihydrochloride
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Catalog number
9488-25
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Price
Please ask
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Size
25 mg
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Alternative_name
(αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride; LY335979
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Description
Zosuquidar is a potent P-glycoprotein (P-gp) inhibitor (Kd = 79 nM). Zosuquidar binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). Restores doxorubicin (Cat. No. 1527) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines.
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CAS Number
167465-36-3
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Structure Available
Yes
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Molecular Formula
C₃₂H₃₁FN₃O.3HCl
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Molecular Weight
636.99
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (>25 mg/ml)
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Handling
Protect from air and moisture
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Tag Line
A potent P-glycoprotein (P-gp) inhibitor
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Storage Condition
-20°C
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Shipping Condition
Gel pack
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Shelf Life
36 months
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MDL Number
MFCD00942300
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PubChem CID
153997
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SMILES
C1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5C6C(C6(F)F)C7=CC=CC=C47.Cl.Cl.Cl
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InChi
InChI=1S/C32H31F2N3O2.3ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;;;/h1-14,21,29-31,38H,15-20H2;3*1H/t21-,29-,30+,31?;;;/m1.../s1
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InChi Key
ZPFVQKPWGDRLHL-ZLYBXYBFSA-N
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MSDS Available
Yes
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