Zosuquidar trihydrochloride

  • Catalog number
    9488-25
  • Price
    Please ask
  • Size
    25 mg
  • Alternative_name
    (αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol trihydrochloride; LY335979
  • Description
    Zosuquidar is a potent P-glycoprotein (P-gp) inhibitor (Kd = 79 nM).  Zosuquidar binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). Restores doxorubicin (Cat. No. 1527) sensitivity in P-gp-expressing multidrug (MDR) resistant cancer cell lines.
  • CAS Number
    167465-36-3
  • Structure Available
    Yes
  • Molecular Formula
    C₃₂H₃₁FN₃O.3HCl
  • Molecular Weight
    636.99
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (>25 mg/ml)
  • Handling
    Protect from air and moisture
  • Tag Line
    A potent P-glycoprotein (P-gp) inhibitor
  • Storage Condition
    -20°C
  • Shipping Condition
    Gel pack
  • Shelf Life
    36 months
  • MDL Number
    MFCD00942300
  • PubChem CID
    153997
  • SMILES
    C1CN(CCN1CC(COC2=CC=CC3=C2C=CC=N3)O)C4C5=CC=CC=C5C6C(C6(F)F)C7=CC=CC=C47.Cl.Cl.Cl
  • InChi
    InChI=1S/C32H31F2N3O2.3ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;;;/h1-14,21,29-31,38H,15-20H2;3*1H/t21-,29-,30+,31?;;;/m1.../s1
  • InChi Key
    ZPFVQKPWGDRLHL-ZLYBXYBFSA-N
  • MSDS Available
    Yes
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