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Alternative_name
(2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
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Description
Zanamivir is a potent and selective inhibitor of influenza A and B virus neuraminidases with IC₅₀ values of 0.95 nM and 2.7 nM, respectively. It interacts with a group of amino acids in the active site of neuraminidase, that are conserved in all influenza A and B strains. Zanamivir blocks the action of neuraminidase, which blocks the cleavage of sialic acid on the cell receptors, thus preventing release and spread of the newly formed virions.
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CAS Number
139110-80-8
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₂H₂₀N₄O7
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Molecular Weight
332.31
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO
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Handling
Protect from air and light
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Tag Line
A potent and selective inhibitor of influenza A and B virus neuraminidases
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD00866966
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PubChem CID
60855
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SMILES
CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)N=C(N)N
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InChi
InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1
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InChi Key
ARAIBEBZBOPLMB-UFGQHTETSA-N
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MSDS Available
Yes