XL019

• Catalog number
  2609-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  (S)-N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide
• Description
  XL019 is a potent, highly selective and reversible JAK2 inhibitor (IC₅₀ = 2.2 nM). Inhibits JAK1 (IC₅₀ = 134.3 nM), JAK3 (IC50 = 214.2 nM) and TYK2 (IC₅₀ = 348.3 nM) at higher concentrations. XL019 displays significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model.
• CAS Number
  945755-56-6
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₂₅H₂₈N₆O₂
• Molecular Weight
  444.53
• Cell Permeable
  Yes
• Purity
  >98% by HPLC
• Solubilities
  DMSO (~ 15 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent JAK2 inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• PubChem CID
  57990869
• PubChem CID Link
• SMILES
  C1CC(NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5
• InChi
  InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2,(H,28,32)(H,27,29,30)/t23-/m0/s1
• InChi Key
  ISOCDPQFIXDIMS-QHCPKHFHSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  XL019  
• Short name
  XL019
• Alternative name
  XL019

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