Vatalanib, Free Base

  • Catalog number
    2026-5
  • Price
    129.59 USD
  • Size
    5 mg
  • Alternative_name
    CGP-79787; PTK 787; ZK222584
  • Description
    Cell-permeable. An inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter.  At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-β (IC₅₀ = 580 nM), c-KIT (IC₅₀ = 730 nM), FLT-4 (IC₅₀ = 660 nM) and c-FMS (IC₅₀ = 1.4 µM).  On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 µM).
  • CAS Number
    212141-54-3
  • Structure Available
    Yes
  • Salt Form
    No
  • Molecular Formula
    C₂₀H₁₅ClN₄
  • Molecular Weight
    346.81
  • Cell Permeable
    Yes
  • Purity
    ≥98% by HPLC
  • Solubilities
    DMSO (25 mg/ml) or EtOH (~ 6 mg/ml)
  • Handling
    Protect from air and moisture
  • Tag Line
    A potent inhibitor of the VEGFR tyrosine kinases
  • Storage Condition
    -20°C
  • Shipping Condition
    gel pack
  • Shelf Life
    24 months
  • MDL Number
    MFCD08458963
  • PubChem CID
    151194
  • SMILES
    C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4
  • InChi
    InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24- 25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
  • InChi Key
    YCOYDOIWSSHVCK-UHFFFAOYSA-N
  • MSDS Available
    Yes
  • Gene target
    Vatalanib   Free   Base  
  • Short name
    Vatalanib, Free Base
  • Alternative name
    Vatalanib, Free Base
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