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Alternative_name
TZ9; (4-amino-6-anilino-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate, (4-amino-6-(phenylamino)-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate; Rad6 inhibitor; HHR6 inhibitor
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Description
TZ9 is a triazine analogue inhibitor of human E2 ubiquitin-conjugating enzyme Rad6B/HHR6B. It docks to the Rad6B catalytic site. It inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and apoptosis of human breast cancer MDA-MB-231 cells. It inhibits proliferation of MDA-MB-231 cells with an IC₅₀ of 6 μM.
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CAS Number
1002789-86-7
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Structure Available
true
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Salt Form
false
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Molecular Formula
C₁₇H₁₄N₆O₄
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Molecular Weight
366.33
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Cell Permeable
True
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Purity
≥98%
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Solubilities
~30 mg/ml in DMSO and DMF in 0
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Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag Line
An inhibitor of Rad6B/HHR6B
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Storage Condition
-20ºC
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Shipping Condition
Gel Pack
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Shelf Life
36 months
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PubChem CID
7593228
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SMILES
C1=CC=C(C=C1)NC2=NC(=NC(=N2)N)COC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
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InChi
InChI=1S/C17H14N6O4/c18-16-20-14(21-17(22-16)19-12-4-2-1-3-5-12)10-27-15(24)11-6-8-13(9-7-11)23(25)26/h1-9H,10H2,(H3,18,19,20,21,22)
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InChi Key
RRRDZFQRNJTKHL-UHFFFAOYSA-N
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MSDS Available
True