TZ9

• Catalog number
  B2835-1
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  TZ9; (4-amino-6-anilino-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate, (4-amino-6-(phenylamino)-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate; Rad6 inhibitor; HHR6 inhibitor
• Description
  TZ9 is a triazine analogue inhibitor of human E2 ubiquitin-conjugating enzyme Rad6B/HHR6B. It docks to the Rad6B catalytic site. It inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and apoptosis of human breast cancer MDA-MB-231 cells. It inhibits proliferation of MDA-MB-231 cells with an IC₅₀ of 6 μM.
• CAS Number
  1002789-86-7
• Structure Available
  true
• Salt Form
  false
• Molecular Formula
  C₁₇H₁₄N₆O₄
• Molecular Weight
  366.33
• Cell Permeable
  True
• Purity
  ≥98%
• Solubilities
  ~30 mg/ml in DMSO and DMF in 0
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  An inhibitor of Rad6B/HHR6B
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  7593228
• PubChem CID Link
• SMILES
  C1=CC=C(C=C1)NC2=NC(=NC(=N2)N)COC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
• InChi
  InChI=1S/C17H14N6O4/c18-16-20-14(21-17(22-16)19-12-4-2-1-3-5-12)10-27-15(24)11-6-8-13(9-7-11)23(25)26/h1-9H,10H2,(H3,18,19,20,21,22)
• InChi Key
  RRRDZFQRNJTKHL-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  True

• Gene target
  TZ9  
• Short name
  TZ9
• Alternative name
  TZ9

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